13.6: Additional Resources

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The following set of experiments introduce students to the applications of chemical kinetic methods, including enzyme kinetic methods, and flow injection analysis.

Chemical Kinetic Methods

Abramovitch, D. A.; Cunningham, L. K.; Litwer, M. R. “Decomposition Kinetics of Hydrogen Peroxide: Novel Lab Experiments Employing Computer Technology,” J. Chem. Educ. 2003, 80, 790–792.
Antuch, M.; Ramos, Y.; Álvarez, R. “Simulated Analysis of Linear Reversible Enzyme Inhibition with SCILAB,” J. Chem. Educ. 2014, 91, 1203–1206.
Bateman, Jr. R. C.; Evans, J. A. “Using the Glucose Oxidase/Peroxidase Systems in Enzyme Kinetics,” J. Chem. Educ. 1995, 72, A240–A241.
Bendinskas, K.; DiJacomo, C.; Krill, A.; Vitz, E. “Kinetics of Alcohol Dehydrogenase-Catalyzed Oxidation of Ethanol Followed by Visible Spectroscopy,” J. Chem. Educ. 1068, 82, 1068–1070.
Clark, C. R. “A Stopped-Flow Kinetics Experiment for Advanced Undergraduate Laboratories: Formation of Iron(III) Thiocyanate,” J. Chem. Educ. 1997, 74, 1214–1217.
Diamandis, E. P.; Koupparis, M. A.; Hadjiionnou, T. P. “Kinetic Studies with Ion-Selective Electrodes: Determination of Creatinine in Urine with a Picrate Ion-Selective Electrode,” J. Chem. Educ. 1983, 60, 74–76.
Dias, A. A.; Pinto, P. A.; Fraga, I.; Bezerra, R. M. F. “Diagnosis of Enzyme Inhibition Using Excel Solver: A Combined Dry and Wet Laboratory Exercise,” J. Chem. Educ. 2014, 91, 1017–1021.
El Seoud, O. A.; Galgano, P. D.; Arêas, E. P. G.; Moraes, J. M. “Learning Chemistry from Good and (Why Not?) Problematic Results: Kinetics of the pH-Independent Hydrolysis of 4-Nitrophenyl Chloroformate,” J. Chem. Educ. 2015, 92, 752–756.
Frey, M. W.; Frey, S. T.; Soltau, S. R. “Exploring the pH Dependence of L-leucine-p-nitroanilide Cleavage by Aminopeptidase Aeromonas Proteolytica: A Combined Buffer-Enzyme Kinetics Experiment for the General Chemistry Laboratory,” Chem. Educator 2010, 15, 117–120.
Gooding, J. J.; Yang, W.; Situmorang, M. “Bioanalytical Experiments for the Undergraduate Laboratory: Monitoring Glucose in Sport Drinks,” J. Chem. Educ. 2001, 78, 788–790.
Hamilton, T. M.; Dobie-Galuska, A. A.; Wietstock, S. M. “The o-Phenylenediamine-Horseradish Peroxidase System: Enzyme Kinetics in the General Chemistry Lab,” J. Chem. Educ. 1999, 76, 642– 644.
Johnson, K. A. “Factors Affecting Reaction Kinetics of Glucose Oxidase,” J. Chem. Educ. 2002, 79, 74–76.
Mowry, S.; Ogren, P. J. “Kinetics of Methylene Blue Reduction by Ascorbic Acid,” J. Chem. Educ. 1999, 76, 970–974.
Nyasulu, F. W.; Barlag, R. “Gas Pressure Sensor Monitored Iodide-Catalyzed Decomposition Kinetics of Hydrogen Peroxide: An Initial Rate Approach,” Chem. Educator 2008, 13, 227–230.
Nyasulu, F. W.; Barlag, R. “Thermokinetics: Iodide-Catalyzed Decomposition Kinetics of Hydrogen Peroxide; An Integrated Rate Approach,” Chem. Educator 2010, 15, 168–170.

Pandey, S.; McHale, M. E. R.; Horton, A. M.; Padilla, S. A.; Trufant, A. L.; De La Sancha, N. U.; Vela, E.; Acree, Jr., W. E. “Kinetics-Based Indirect Spectrophotometric Method for the Simultaneous Determination of \(\text{MnO}_4^-\) and \(\text{Cr}_2 \text{O}_7^{2-}\),” J. Chem. Educ. 1998, 75, 450–452.
Stock, E.; Morgan, M. “A Spectroscopic Analysis of the Kinetics of the Iodine Clock Reaction without Starch,” Chem. Educator 2010, 15, 158–161.
Vasilarou, A.-M. G.; Georgiou, C. A. “Enzymatic Spectrophotometric Reaction Rate Determination of Glucose in Fruit Drinks and Carbonated Beverages,” J. Chem. Educ. 2000, 77, 1327–1329.
Williams, K. R.; Adhyaru, B.; Timofeev, J.; Blankenship, M. K. “Decomposition of Aspartame. A Kinetics Experiment for Upper-Level Chemistry Laboratories,” J. Chem. Educ. 2005, 82, 924–925.

Flow Injection Methods

Carroll, M. K.; Tyson, J. F. “An Experiment Using Time-Based Detection in Flow Injection Analysis,” J. Chem. Educ. 1993, 70, A210–A216.
ConceiÇão, A. C. L.; Minas da Piedade, M. E. “Determination of Acidity Constants by Gradient Flow-Injection Titration,” J. Chem. Educ. 2006, 83, 1853–1856.
Hansen, E. H.; Ruzicka, J. “The Principles of Flow Injection Analysis as Demonstrated by Three Lab Exercises,” J. Chem. Educ. 1979, 56, 677–680.
McKelvie, I. D.; Cardwell, T. J.; Cattrall, R. W. “A Microconduit Flow Injection Analysis Demonstration using a 35-mm Slide Projector,” J. Chem. Educ. 1990, 67, 262–263.
Meyerhoff, M. E.; Kovach, P. M. “An Ion-Selective Electrode/Flow Injection Analysis Experiment: Determination of Potassium in Serum,” J. Chem. Educ. 1983, 60, 766–768.
Nóbrega, J. A.; Rocha, F. R. P. “Ionic Strength Effect on the Rate of Reduction of Hexacyanoferrate(II) by Ascorbic Acid,” J. Chem. Educ. 1997, 74, 560–562.
Ríos, A.; Luque de Castro, M.; Valcárcel, M. “Determination of Reaction Stoichiometries by Flow Injection Analysis,” J. Chem. Educ. 1986, 63, 552–553.
Stults, C. L. M.; Wade, A. P.; Crouch, S. R. “Investigation of Temperature Effects on Dispersion in a Flow Injection Analyzer,” J. Chem. Educ. 1988, 65, 645–647.
Wolfe, C. A. C.; Oates, M. R.; Hage, D. S. “Automated Protein Assay Using Flow Injection Analysis,” J. Chem. Educ. 1998, 75, 1025–1028.

The following sources provides a general review of the importance of chemical kinetics in analytical chemistry.

Bergmyer, H. U.; Grassl, M. Methods of Enzymatic Analysis, Verlag Chemie: Deerfield Beach, FL, 3rd Ed., 1983.
Doménech-Carbó, A. “Dating: An Analytical Task,” ChemTexts 2015, 1:5.
Laitinen, H. A.; Ewing, G. W., eds., A History of Analytical Chemistry, The Division of Analytical Chemistry of the American Chemical Society: Washington, D. C., 1977, pp. 97–102.
Malmstadt, H. V.; Delaney, C. J.; Cordos, E. A. “Reaction-Rate Methods of Chemical Analysis,” Crit. Rev. Anal. Chem. 1972, 2, 559–619.
Mark, H. B.; Rechnitz, G. A. Kinetics in Analytical Chemistry, Wiley: New York, 1968.
Mottola, H. A. “Catalytic and Differential Reaction-Rate Methods of Chemical Analysis,” Crit. Rev. Anal. Chem. 1974, 4, 229–280.
Mottola, H. A. “Some Kinetic Aspects Relevant to Contemporary Analytical Chemistry,” J. Chem. Educ. 1981, 58, 399–403.
Mottola, H. A. Kinetic Aspects of Analytical Chemistry, Wiley: New York, 1988.
Pardue, H. L. “A Comprehensive Classification of Kinetic Methods of Analysis Used in Clinical Chemistry,” Clin. Chem. 1977, 23, 2189–2201.
Pardue, H. L. “Kinetic Aspects of Analytical Chemistry,” Anal. Chim. Acta, 1989, 216, 69–107.
Perez-Bendito, D.; Silva, M. Kinetic Methods in Analytical Chemistry, Ellis Horwood: Chichester, 1988.
Pisakiewicz, D. Kinetics of Chemical and Enzyme-Catalyzed Reactions, Oxford University Press: New York, 1977.

The following instrumental analysis textbooks may be consulted for further information on the detectors and signal analyzers used in radiochemical methods of analysis.

Skoog, D. A.; Holler, F. J.; Nieman, T. A. Principles of Instrumental Analysis, 5th Ed., Saunders College Publishing/Harcourt Brace and Co.: Philadelphia., 1998, Chapter 32.
Strobel, H. A.; Heineman, W. R. Chemical Instrumentation: A Systematic Approach, 3rd Ed., Wiley-Interscience: New York, 1989.

The following resources provide additional information on the theory and application of flow injection analysis.

Andrew, K. N.; Blundell, N. J.; Price, D.; Worsfold, P. J. “Flow Injection Techniques for Water Monitoring,” Anal. Chem. 1994, 66, 916A–922A.
Betteridge, D. “Flow Injection Analysis,” Anal. Chem. 1978, 50, 832A–846A.
Kowalski, B. R.; Ruzicka, J. Christian, G. D. “Flow Chemography - The Future of Chemical Education,” Trends Anal. Chem. 1990, 9, 8–13.
Mottola, H. A. “Continuous Flow Analysis Revisited,” Anal. Chem. 1981, 53, 1312A–1316A.
Ruzicka, J. “Flow Injection Analysis: From Test Tube to Integrated Microconduits,” Anal. Chem. 1983, 55, 1040A–1053A.
Ruzicka, J.; Hansen, E. H. Flow-Injection Analysis, Wiley-Interscience: New York, 1989.
Ruzicka, J.; Hansen, E. H. “Retro-Review of Flow-Injection Analysis,” Trends Anal. Chem. 2008, 27, 390–393.
Silvestre, C. I. C.; Santos, J. L. M.; Lima, J. L. F. C.; Zagatto, E. A. G. “Liquid-Liquid Extraction in Flow Analysis: A Critical Review,” Anal. Chim. Acta 2009, 652, 54–65.
Stewart, K. K. “Flow Injection Analysis: New Tools for Old Assays, New Approaches to Analytical Measurements,” Anal. Chem. 1983, 55, 931A–940A.
Tyson, J. F. “Atomic Spectrometry and Flow Injection Analysis: A Synergic Combination,” Anal. Chim. Acta, 1988, 214, 57–75.
Valcarcel, M.; Luque de Castro, M. D. Flow-Injection Analysis: Principles and Applications, Ellis Horwood: Chichester, England, 1987.

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