Analytical Chemistry
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- 25125
- Supplemental Modules (Analytical Chemistry)
- Analytical Sciences Digital Library
- Active Learning
- Affinity Chromatography
- Analytical Electrochemistry: The Basic Concepts
- Analytical Electrochemistry: Potentiometry
- Atomic Emission Spectroscopy (AES)
- Chemical Equilibrium
- Introduction to Data Analysis
- Introduction to Lasers
- Introduction to Mass Spectrometry
- In Class Activities
- Introduction to Data and the Analysis of Data
- Separation Science
- Electrochemical Methods of Analysis
- In-class Problems
- Text
- Learning Objectives
- Instructor’s Manual
- Biological Mass Spectrometry: Proteomics
- Nuclear Magnetic Resonance Spectroscopy
- Interpreting the Primary Literature
- Comparing Analytical Methods Assignment
- Acid-Base Chemistry Assignment
- Separations Assignment
- Spectroscopy Assignment
- Mass Spectrometry Assignment
- Electrochemistry Assignment
- Instructor’s Manual
- Comparing Analytical Methods: Cocaine Determination in Urine
- Acid-Base Equilibria: Titrations of Bacterial Cell Surfaces
- Separations: Colloidal Particle Column Packings
- Spectroscopy: Infochemistry using Atomic Emission Beacons
- Mass Spectrometry: Fruit Fly Proteomics and Aging
- Electrochemistry: Fast Scan Cyclic Voltammetry in Drug-Seeking Rats
- Concentration Calibration
- Molecular and Atomic Spectroscopy
- In Class Problems: Molecular Spectroscopy
- In-class Questions: General Background on Molecular Spectroscopy
- Out-of-class Questions: Instrumental Setup of a Spectrophotometer
- In-class Questions: Ultraviolet/Visible Absorption Spectroscopy
- In-class Questions: Molecular Luminescence
- In-class Questions: Infrared Spectroscopy
- In-class Questions: Raman Spectroscopy
- In Class Problems: Atomic Spectroscopy
- Book: Molecular and Atomic Spectroscopy
- 1: General Background on Molecular Spectroscopy
- 2: Ultraviolet/Visible Absorption Spectroscopy
- 3: Molecular Luminescence
- 4: Infrared Spectroscopy
- 5: Raman Spectroscopy
- 6: Atomic Spectroscopy
- Learning Objectives: Molecular and Atomic Spectroscopy
- Instructor’s Manual – Molecular and Atomic Spectroscopy
- In-class Questions: General Background on Molecular Spectroscopy
- Out-of-class Questions: Instrumental Setup of a Spectrophotometer
- In-class Questions: Ultraviolet/Visible Absorption Spectroscopy
- In-class Questions: Molecular Luminescence
- In-class Questions: Infrared Spectroscopy
- In-class Questions: Raman Spectroscopy
- In Class Problems: Atomic Spectroscopy
- In Class Problems: Molecular Spectroscopy
- Mass Spectrometry: LEGO Exercise
- Laboratory Activities
- Acid Mine Drainage Project Lab
- Analysis of Phosphorus Concentrations in a Natural Water System
- Quality Control Analysis for a Local Brewery
- Theme-Based Lab Experience
- Instructor’s Manual
- Using This Guide
- A Theme-Based Modular Approach
- Student Learning Objectives
- Logistics of Using Theme-Based Modules at Butler University
- Selection of the Instructor for the Theme-Based Analytical Laboratory Course
- Choosing Themes and Projects
- Example Themes That Have Been Used
- Student Use of Time
- Controlling Group Dynamics
- Deliverables Required from the Students
- Grading
- The Use of Peer-Review
- Concluding Comments About the Use of Theme-Based Modules at Butler?
- Instructor’s Manual
- Contextual Modules
- JASDL
- Courseware
- Affinity Chromatography
- Analytical Electrochemistry: The Basic Concepts
- Atomic Emission Spectroscopy (AES)
- Chemical Equilibrium
- In-class Problems
- Text
- Overview: Significance of Chemical Equilibrium
- Acid-Base Chemistry
- Solution of a Weak Base
- Nomenclature of Acids and Bases
- Solution Containing a Conjugate Pair (Buffer)
- Solution of a Weak Acid
- Solutions that are Mixtures of Acids and Bases, Problem A
- Solutions that are Mixtures of Acids and Bases, Problem B
- Acid/Base Properties of Amino Acids
- Titration of a Weak Base
- Solutions of Polyprotic Acid/Base Systems, Problem A
- Solutions of Polyprotic Acid/Base Systems, Problem B
- Solutions of Polyprotic Acid/Base Systems, Problem C
- Solutions of Polyprotic Acid/Base Systems, Problem D
- Solutions of Polyprotic Acid/Base Systems, Problem E
- Titration of a Polyprotic Weak Acid with Sodium Hydroxide
- Water-Soluble Complexes
- Mass and Charge Balances
- Solubility Equilibria
- Learning Objectives
- Instructor's Manual
- Overview: Significance of Chemical Equilibrium
- Acid-Base Chemistry
- Solution of a Weak Base
- Solution Containing a Conjugate Pair (Buffer)
- Solution of a Weak Acid
- Solutions that are Mixtures of Acids and Bases, Problem A
- Solutions that are Mixtures of Acids and Bases, Problem B
- Titration of a Weak Base
- Solutions of Polyprotic Acid/Base Systems, Problem A
- Solutions of Polyprotic Acid/Base Systems, Problem B
- Solutions of Polyprotic Acid/Base Systems, Problem C
- Solutions of Polyprotic Acid/Base Systems, Problem D
- Solutions of Polyprotic Acid/Base Systems, Problem E
- Water-Soluble Complexes
- Solubility Equilibria
- Out-of-class Problems
- Vignettes
- Teaching Instrumental Analysis without a Textbook
- What is Instrumental Analysis? / Data domains
- Digital Electronics
- Signals and Noise/DAQ Lab
- Electromagnetic Radiation
- Introduction to Optical Spectroscopy
- More Optical Spectroscopy
- Introduction to Atomic Spectroscopy
- Atomic Absorption
- Atomic Emission
- X-ray Fluorescence
- Preparation of Lab Report/Critical Journal Reading
- Instrumentation for Molecular Absorption Spectroscopy
- Applications of Molecular Absorption Spectroscopy
- Molecular Luminescence Spectroscopy
- Infrared Spectroscopy
- Instrumentation for Infrared Spectroscopy
- Nuclear Magnetic Resonance Spectroscopy (NMR)
- Applications of NMR
- Mass Spectrometry
- Mass Spectrometry, continued
- Re-introduction to Chromatography
- Gas Chromatography
- Liquid Chromatography/ Capillary Electrophoresis
- Introduction to Lasers
- Introduction to XRF- An Analytical Perspective
- Introduction to X-ray Diffraction (XRD)
- Separation Science
- In-class Problems
- Text
- Learning Objectives
- Instructor's Manual
- Out-of-class Problems
- Laboratory Projects
- Specialty Topics
- Vignettes
- CHEM355: A Flipped Analytical Chemistry Course (Fitzgerald)
- Prezi presentation - Flipped Course Workshop
- Chapter 1: Introduction
- Chapter 2: Basic Tools of Analytical Chemistry
- Chapter 3: The Language of Analytical Chemistry
- Chapter 4: Evaluating Analytical Data
- Chapter 5: Calibrations, Standardizations, and Blank Corrections
- Chapter 6: Equilibrium Chemistry
- Chapter 7: Collecting and Preparing Samples
- Chapter 8: Gravimetric Methods
- Chapter 9: Titrimetric Methods
- Chapter 10: Spectroscopic Methods
- Chapter 11: Electrochemical Methods
- Chapter 12: Chromatographic and Electrophoretic Methods
- Chapter 13: Kinetic Methods
- Introduction to Signals and Noise
- Quantitative NMR
- Goals and Objectives
- Basic NMR Theory
- 1. What is spin?
- 2. How does absorption of energy generate an NMR spectrum?
- 3: How does the population difference in NMR compare to the difference between electronic ground and excited states?
- 4: What is chemical shift and how does it relate to resonance frequency?
- 5. What is precession?
- 6. How does precession generate the macroscopic magnetization (Mo)?
- 7. How can the nuclear spins be manipulated to generate the NMR spectrum?
- 8. What is the tip angle?
- 9. What is the Free Induction Decay?
- 10. How do T₁ and T₂ relaxation affect NMR spectra?
- 11. Where should I look to learn more about NMR?
- Practical Aspects of Q-NMR
- 1. How do I choose a reference standard for my Q-NMR analysis?
- 2. How is the internal standard used to quantify the concentration of my analyte?
- 3. What sample considerations are important?
- 4. How do I choose the right acquisition parameters for a quantitative NMR measurement?
- 5. What data processing considerations are important for obtaining accurate and precise results?
- References
- Virtual Experiment
- Q-NMR Experiment
- Q-NMR Applications
- Q-NMR for purity determination of macrolide antibiotic reference standards: Comparison with the mass balance method
- Determining Enantiomeric or Isomeric Purity of Active Pharmaceutical Ingredients
- Q-NMR for Analysis and Characterization in Vaccine Preparations
- Q-NMR-Based Metabonomics of Blood Samples
- Q-NMR for Time Course Evolution of Malic and Lactic Acid
- Advanced Theory
- Other Resources
- Instructor's Guide
- Analytical Electrochemistry: Potentiometry
- Green Chemistry
- Chapter 1. Chemistry, Green Chemistry, and Environmental Chemistry
- 1.1. Chemistry is Good
- 1.2. The Environment and the Five Environmental Spheres
- 1.3. What is Environmental Chemistry?
- 1.4. Environmental Pollution
- 1.5. What is Green Chemistry?
- 1.6. Green Chemistry and Synthetic Chemistry
- 1.7. Reduction of Risk: Hazard and Exposure
- 1.8. The Risks of No Risks
- 1.9. Waste Prevention
- 1.10. Twelve Principles of Green Chemistry
- 1.11. Some Things to Know About Chemistry Before You Even Start
- 1.12. Combining Atoms to Make Molecules and Compounds
- 1.13. Chemical Reactions
- 1.14. The Nature of Matter and States of Matter
- Chapter 2. The Elements: Basic Building Blocks of Green Chemicals
- 2.1. Elements, Atoms, and Atomic Theory
- 2.2. Hydrogen, The Simplest Atom
- 2.3. Helium, The First Noble Gas
- 2.4. Lithium, The First Metal
- 2.5. The Second Period of the Periodic Table
- 2.6. The Magic Octet of 8 Outer-Shell Electrons
- 2.7. Completing the 20-Element Periodic Table
- 2.8. The Brief Periodic Table is Complete
- Chapter 3. Compounds: Safer Materials for a Safer World
- 3.1. Chemical Bonds and Chemical Compounds
- 3.2. Electrons Involved in Chemical Bonds and Octets of Electrons
- 3.3. Sodium Chloride and Ionic Bonds
- 3.4. Covalent Bonds in H2 and Other Molecules
- 3.5. Covalent Bonds in Compounds
- 3.6. Covalent Bonds and Green Chemistry
- 3.7. Predicting Formulas of Covalently Bound Compounds
- 3.8: Chemical Formulas, the Mole, and Percentage Composition
- 3.9. What Are Chemical Compounds Called?
- 3.10. Acids, Bases, and Salts
- Chapter 1. Chemistry, Green Chemistry, and Environmental Chemistry
- Labware
- An Instrumental Electroanalytical Experiment: Determination of Pb and Cd in Cigarettes Using Anodic Stripping Voltammetry
- Analog and Digital Conversion for Chemical Instrumentation
- A Microchip Capillary Electrophoresis Experiment for the Instrumental Analysis Laboratory
- Cell Phone Spectrophotometer
- Electrochemical Detection of Phenol Utilizing a Sythesized Sonogel-Carbon Ziconium Oxide
- Analytical Electrochemistry: A Laboratory Manual
- Commentary
- Experiments
- 1. Cyclic Voltammetry At Solid Electrodes
- 2. Cyclic Voltammetry With A Microelectrode
- 3. Chronoamperometry With a Planar Solid Electrode
- 4. The Cyclic Voltammetry of Dopamine: an EC mechanism (Experiment)
- 5. Analysis of Trace Lead in Water by Anodic Stripping Voltammetry
- 6. Acetaminophen (Tylenol): Electroanalytical Study of Acetaminophen (APAP) by Cyclic Voltammetry
- 7. Ascorbic Acid (Vitamin C): A Cyclic Voltammetric Study of its Oxidation at a Glassy Carbon Electrode
- Tech Notes
- Synthesis of Sonogel-Carbon Modified Electrode with Titanium Oxide
- Teaching Chemical Analysis Concepts Using Field-Lab Experiences in a Multi-Disciplinary Integrated Environment
- Electrochemistry and Detection of Organic and Biological Molecules
- Adapting the Chemical Analysis of Paintings
- Project -Based Learning
- Art as a Teaching Tool in Science Curricula
- Analytical Chemistry applied to Art Studies
- Outline of Analytical Methods used for Paint Analysis
- Experience using PBL of Art Objects for Instrumental Analysis Lab
- Lessons learned using this initial PBL approach
- Summary
- Project Update. Spring 2006 (Feb 2006)
- Literature Cited
- Micro Separations Distance: Capillary Electrophoresis
- SOP / Protocols
- Fabrication of a Capillary Electrophoresis System
- Operation of a Capillary Electrophoresis System
- 0. Safety
- 1. Solution Preparation
- 2. Cutting a New Capillary
- 3. Installing a New Capillary
- 4. Conditioning a New Capillary
- 5. Daily System Preparation
- 6. Initiating the IGOR Pro Software
- 7. Establishing a Baseline (FIA)
- 8. Establishing Baseline (CE)
- 9. FIA: Flow Injection Analysis (pressure only, NO voltage)
- 10. Capillary Electrophoresis (voltage only, no pressure)
- 11. Sample Injection
- 12. Data Analysis
- Learning Modules
- SOP / Protocols
- Forensic Science Laboratory
- Alcohol
- Arson
- Drugs (Blood)
- Drugs (Bulk)
- Explosives
- Fabric
- Glass
- Gunshot Residue
- Paint
- Pen Ink
- Stories
- Case of the Bloodied Bully
- Case Report
- Photographs of the Crime Scene
- Sketch of Crime Scene
- Autopsy Report
- Officer's statement: DSG Ruth Hook
- Officer's Report: Timothy Larsen
- Fire Report: Leonard Hartman
- Witness Statement: Camilla Berry
- Witness Statement: Richard Neilson
- Witness Statement: Michael Brown
- Witness Statement: Donna Stevens
- Witness Statement: Caroline Stevens
- Witness Statement: Christopher Gunn
- Witness Statement: Charles Johnson
- Case Report
- Case of the Trampled Teen
- Case of the Tampered Testament
- Case of the Bloodied Bully
- Courseware
- Active Learning
- Chromedia
- Gas Chromotography (GC)
- Gas Chromotography: Basic Theory
- Introduction to GC
- The Separation Process (A)
- Introduction to GC (V)
- GC Instrumentation. (V)
- GC capillary columns (V)
- GC detectors (V)
- Quantitative and qualitative analysis (V)
- Separation parameters in GC
- The resolution equation
- Selectivity (A)
- Resolution 1 variable. (A)
- Resolution Tool (3 variables) (A)
- The Van Deemter equation
- A-Term: eddy diffusion (A)
- B-term: longitudinal diffusion (A)
- Parameters influencing retention time
- Peak width and peak broadening
- GC resolution master class (V)
- GC resolution whiteboard tutorial (V)
- How to use the resolution tool (V)
- Plate height equations
- Asymmetry factor (A)
- GC temperature programming (V)
- Temperature programming (A)
- Qualitative analysis: identification
- Rules of thumb & checklist
- Some 'bad' GC chromatograms
- FAQ's
- GC basics course
- Gas Chromotography: Animations
- The Separation Process (A)
- A-Term: eddy diffusion (A)
- B-term: longitudinal diffusion (A)
- Selectivity (A)
- Resolution 1 variable. (A)
- Resolution Tool (3 variables) (A)
- Temperature programming (A)
- Asymmetry factor (A)
- The retention gap (A)
- Cold trapping and solvent effect (A)
- Cold trapping or thermal focussing (A)
- FID: Flame Ionisation detector (A)
- ECD: Electron Capture Detector (A)
- NPD: Nitrogen Phosphorus Detector (A)
- FPD: Flame Photometric Detector (A)
- Pulsed FPD (A)
- TCD: Thermal Conductivity Detector (A)
- Gas Chromotography: In Practice
- Introduction
- Gas Chromatography: Injection techniques and principles
- Injection principles of capillary GC
- Injection techniques
- Direct injection
- Manual syringe injection
- Comparison of injectors
- The septum
- Introduction to Capillary GC injection techniques.
- Cold on-column injection
- Cold trapping and solvent effect (A)
- Cold trapping or thermal focussing (A)
- The retention gap
- The retention gap (A)
- The PTV injector
- Programmed Temperature Vaporization (PTV) injection
- On-column large volume injection
- Techniques for PTV-LVI
- Optimisation
- LVI using speed controlled sampling
- Thermodesorption
- Headspace analysis
- Dynamic headspace & purge-and-trap
- Liners
- Splitless injection
- Flow control and pressure regulation
- Cold trapping or thermal focussing
- Cold trapping or thermal focussing (A)
- Solvent effect
- Split injection
- Introduction
- Method development
- Fundamentals of the hardware
- Basic Operation
- Setting Temperatures and Flows
- What Really Happens in the Glass Liner
- What Really Happens in the Syringe
- Method Development Issues
- Installation of a capillary column to a split injector
- Gas Chromatography: Column types
- Gas Chromatography: Detectors
- GC detection principles:
- GC detector characteristics:
- FID: Flame Ionisation detector
- FID: Flame Ionisation detector (A)
- ECD: Electron Capture Detector
- ECD: Electron Capture Detector (A)
- FPD: Flame Photometric Detector
- FPD: Flame Photometric Detector (A)
- Pulsed FPD (A)
- NPD: Nitrogen Phosphorus Detector
- NPD: Nitrogen Phosphorus Detector (A)
- TCD: Thermal Conductivity Detector
- TCD: Thermal Conductivity Detector (A)
- PID: Photo Ionisation Detector
- AED: Atomic Emission Detector
- Chemiluminescence Detector
- Helium Ionisation Detector
- Hall Electrolytic Conductivity Detector
- Problems when lighting an FID
- Gas Chromatography: Troubleshooting
- How to avoid trouble
- Diagnosing 'bad' chromatograms
- Before you call the service dept!
- GC troubleshooting advanced course
- GC troubleshooting advanced course
- Systematic problem solving
- Rules of thumb & checklist
- The gas system
- Injection
- The column
- The detector
- Some 'bad' GC chromatograms
- Troubleshooting in GCxGC
- An overview from practice
- Problems with pesticides analysis
- Gas Chromatography: Sample Prep
- How to select a technique
- Introduction
- Introduction to Sample Treatment (ST)
- ST in analytical chemistry
- How to select a technique
- The GC Sample Preparation Circle
- Webinar Sample preparation
- Q&A Webinar Sample prep April 2010
- Sample handling: a rational approach
- Factorial design. Why?
- Factorial design. How does it work?
- Factorial design in 7 easy steps
- SPME
- Interview Janusz Pawliszyn at Pittcon 2011
- SPME in perspective
- Principles of SPME
- Experimental parameters affecting extraction efficiency
- Interfacing and automating
- Method development and optimization
- Optimization of desorption conditions
- Selection of the calibration method
- Method evaluation
- References
- Food and fragrance studies involving SPME
- Passive Sampling
- 2-D Gas Chromotography
- Fast Gas Chromotography
- Gas Chromotography: Basic Theory
- Liquid Chromatography (LC)
- Liquid Chromatography (basic theory)
- Introduction to LC
- The role of separation techniques
- The separation process
- The separation process (A)
- Separation parameters
- Selectivity (A)
- The resolution equation
- The resolution equation (A)
- Eddy diffusion (A-term) (A)
- Longitudinal diffusion(B-term) (A)
- Resolution and peak overlap (A)
- Separation & peak overlap
- Peak width and peak broadening
- The Van Deemter equation
- Resolution in LC. Master Class (V)
- Resolution. Whiteboard tutorial (V)
- The resolution tool (V)
- Effect of parameters on resolution
- Effect of parameters on chromatogram
- Chromatogram generator
- Test your know-how
- Resolution tool sliders
- Liquid Chromatography in practice
- Introduction
- The HPLC system, basics
- Introduction to HPLC columns
- Injection valves
- Solvent system essentials
- Fittings, nut, ferrules
- LC pumps
- Single stroke piston pump
- Dual piston reciprocating pumps
- Pulse dampener (A)
- LC pumps: Reciprocal constant flow (A)
- Pneumatic pump (A)
- Diaphragm pump
- How to avoid trouble
- Malfunctions, wear, salt formation
- Before you call the service dept!
- LC Separation modes
- Guidelines for method choice
- LC Columns
- LC Detectors
- Troubleshooting in LC
- Troubleshooting LC, basics
- How to avoid trouble
- Top tips from practice
- Systematic problem solving
- Pressure problems
- Peak problems
- Resolution problems
- Bad column stability
- Baseline problems
- The pump
- Injection
- The column
- Mobile phase
- Detection
- Diagnosing 'bad' chromatograms
- More 'bad' LC chromatograms
- How to use and regenerate columns
- Bad retention time stability
- LC troubleshooting advanced course
- Before you call the service dept!
- Introduction
- Normal Phase Liquid Chromatography (NPLC)
- Reversed Phase Liquid Chromatography (RPLC)
- Introduction
- Introduction
- Stationary phases
- Physical & Chemical properties
- Retention and Selectivity
- Chemical and thermal stability
- Reproducibility and repeatability
- Hybrid stationary phases
- Mobile phase composition
- How to select the right column
- Column ranking & selection guidance
- Column selection for pharma and compendial analysis
- RPLC Retention Models
- Temperature Effects & Programming
- Gradient Elution
- Introduction to Gradient Elution
- Video Master Class: Gradient Elution
- Gradient systems
- Setting up a gradient
- Gradient elution: setting parameters (A)
- Gradient troubleshooting
- Transfer of gradient methods
- Training tool for transfer
- Gradient transfer calculation tool
- Theory 1: The gradient equation
- Theory 2: Peak capacity
- Advantages & disadvantages
- Ion Suppression & Ion Pair Chromatography
- RPLC Retention Models
- Optimization
- Optimization (advanced)
- Improving the separation
- How to manipulate a separation
- Parameters that affect separation
- Normal-phase liquid chromatography
- Reversed-phase liquid chromatography
- Ion exchange chromatography
- Ion pairing (ion interaction) chromatography
- Simplifying the separation
- Optimization of isocratic separations
- Optimisation of gradient elution
- PRACTICAL MOBILE PHASE OPTIMIZATION
- SYSTEM OPTIMIZATION
- OBJECTIVE OF THE SEPARATION
- The Chromatogram Generator
- About the chromatogram generator
- Downloading the generator
- Lesson 1. Creating your chromatograms
- Lesson 1. How does the generator work?
- Lesson 1. How to use the generator?
- Lesson 1. Some necessary basics
- Lesson 1. Exercise Pressure
- Ecercise explanation: Pressure
- Lesson 1. Exercise Particle size
- Exercise explanation: Particle size
- Lesson 1. Exercise Column length
- Exercise explanation: Column length
- Lesson 1. Combining all parameters
- Explanation: combining all parameters
- Chromatogram generator. Lesson 2
- Lesson 2 Introduction
- Part 1: Monolithic columns
- Exercise 1 Monolithic column
- Exercise 1. Results and background
- Effect of domain size
- Explanation of effect of domain size
- Summary of exercise 1
- Part 2: Porous shell particles
- Exercise 2: Porous shell particles
- Exercise 2 results & explanation
- Lesson 2 Summary
- Introduction
- Liquid Chromatography (Animations)
- The separation process (A)
- Selectivity (A)
- The resolution equation (A)
- Eddy diffusion (A-term) (A)
- Longitudinal diffusion(B-term) (A)
- Resolution and peak overlap (A)
- Peak symmetry and asymmetry (A)
- Chromatogram generator (A)
- LC pumps: Reciprocal constant flow (A)
- Single stroke piston pump
- Dual piston reciprocating pumps
- Serial dual piston reciprocating pump (A)
- Pulse dampener (A)
- Pneumatic pump (A)
- Diaphragm pump
- Quadrupole analyzer (A)
- TOF (Time-of-flight) analyzer (A)
- TOF with Reflectron (A)
- Ion Suppression: pH effect (A)
- Ion Suppression: Effect on retention (A)
- IPC (Ion Pair Chromatography) (A)
- Gradient elution: setting parameters (A)
- Liquid Chromatography (basic theory)
- Ultra High Performance Liquid Chromatography (UHPLC)
- Ultra High Performance Liquid Chromatography (UHPLC)
- Very High Pressures in LC
- Instrumentation for UHPLC
- UHPLC Columns
- UHPLC MS
- Applications of UHPLC–MS
- Detection in UHPLC bioanalysis
- Clever choices for optimization
- Method transfer between HPLC and UHPLC
- Gradient Delay Volume in UHPLC
- Extra-column Band Spreading in UHPLC
- UHPLC in pharmaceutical analysis (video)
- Sample preparation in modern bioanalysis
- 1. Conventional sample prep
- 2. Modern sample preparation
- 3. Microextractions
- Mass spectrometric detection in bioanalysis
- Analytical Strategies for doping analyses
- UHPLC MS in Doping Control Analysis
- Prohibited List: substances and methods
- 2-Dimensional LC
- Nano-LC and applications
- Ultra High Performance Liquid Chromatography (UHPLC)
- Capillary Electrophoresis (CE)
- Capillary Electrophoresis (CE)
- Ion Chromatography (IC)
- Topic Outline
- Separation of ionic compounds
- Ion Exchange Chromatography (IEC)
- Introduction to ion chromatography
- Criteria for separation and detection
- Detection in ion chromatography (IC)
- Ion detection
- Anion exchange chromatography (HPIC)
- Stationary phases
- Styrene/Divinylbenzene Copolymers
- Polymethacrylate and Polyvinyl Resins
- Super-critical Fluid Chromatography (SFC)
- Chiral Chromatography
- STEREOSELECTIVE ANALYSIS & CHROMATOGRAPHY
- Principles of stereochemistry
- PRINCIPLES of CHIRAL SEPARATION
- Indirect LC enantiomer separation
- Direct LC enantiomer separation
- General elution modes
- CHIRAL STATIONARY PHASES:
- 1. Coated Polysaccharide-based CSPs
- 2. Immobilized polysaccharide CSPs
- > Solvent compatibilities of 1 and 2
- 3. Protein CSPs
- 4. Synthetic polymer CSPs
- 5. Cyclodextrin(CD)-based CSPs
- 6. Macrocyclic antibiotics CSPs
- 7. Donor-acceptor (Brush/Pirkle-type) CSPs
- 8. Chiral crown-ether CSPs
- 9. Chiral anion-exchangers
- 10.Chiral ligand-exchange CSPs
- Column Selection & Method Development
- Analysis of enantiomer composition
- Enantiomeric impurity determination
- Links to important column suppliers
- Size Exclusion Chromatography (SEC)
- Field Flow Fractionation (FFF)
- Spectrometry
- Spectrometry (basics)
- UV/Vis spectrometry
- Fluorimetry & XRF
- Raman spectrometry
- Infrared spectrometry
- AAS & AES
- NMR spectrometry
- Introduction to NMR (Text and V)
- How it works (A)
- Instrument Essentials (A)
- Nuclear Spin explained (Text and A)
- NMR and spin explained with a bicycle wheel (V)
- Ethanol spectrum explained (A)
- Integrating the peak area (A)
- Chemical shift and shielding (T and V)
- Magnetic vs chemical equivalence (A)
- Electronegativity and Shielding (A)
- Electronegativity and shielding (V)
- Train and test spectrum interpretation (A)
- Where is NMR used (T)
- The NMR measurement (T and V)
- How to prepare for an NMR experiment
- Training tools
- Mass Spectrometry (MS)
- Chemometrics
- Sample Treatment
- Method Development
- Introduction
- Classification of methods
- When to use methods?
- Strategy for selective sample treatment and detection.
- To initiate a method
- Checklist for method development
- Optimizing a method, Introduction
- Implementing a separation
- Validating a method
- Reporting
- Chromatogram generator
- About the chromatogram generator
- Gradient transfer calculation tool
- Clever choices for optimization
- Quality
- The Flipped Classroom
- Introduction
- Quant curriculum (Videos), presented by Chris Harrison
- Analytical chemistry overview, calculations
- Measuring Tools & Measurements
- Distributions & Statistical Analysis
- Sampling & Equilibrium
- Acid-Base Equilibrium
- Buffers
- Activity coefficients & Equilibria
- Titrimetric Analyses - acid-base
- Titrimetric Analyses - complexation & redox
- Titrimetric Analyses - precipitations
- Standardization & Calibration
- Electrochemical Analyses
- Spectroscopic Analyses
- Chromatography & Electrophoresis
- Instrumental Analysis (Videos), created by Mary Kate Donais
- Intro to Analytical Chemistry and Calibration
- Accuracy, Errors and Data Significance
- Selecting a Method; Figures of Merit
- Electronics and Computers
- Signals and Noise
- Electromagnetic Spectrum (EMS)
- Instrument Components
- Fourier Transform
- Flame Atomic Absorption Spectroscopy (FAAS)
- Mass Spectrometry basics (Video)
- ICP-MS
- X-ray Fluorescence Spectrometry (XRF)
- UV/VIS
- Luminescence
- Infrared Spectrometry
- Raman Spectrometry
- Electrochemistry
- Molecular Mass Spectrometry
- Chromatographic Separations
- Gas Chromatography
- Liquid Chromatography
- Capillary Electrophoresis (CE)
- Application areas
- Food
- Pesticides
- Pharmacy
- Research and Development in the Pharmaceutical Industry
- Separation techniques in pharmaceutical analysis
- Recent developments
- Release and stability analysis
- Lipophilicity of drug like molecules with HPLC
- SFC for Chiral separation in Pharmaceutical Industry
- Jean-Luc Veuthey: Introduction
- About the authors
- LC in Pharma: Fast LC methods (video)
- LC methods in pharma: High Resolution (video)
- Use of High Temperature in pharmaceutical analysis (Video)
- Peptides and Proteins (video)
- Overview of LC analysis in drug metabolism
- LC in Pharma: Fast LC methods (video)
- Metabolomics
- Proteomics
- The Importance of Proteomics
- What is proteomics? (Advanced)
- Peptide mass fingerprinting
- Peptide Fingerprinting and Tandem Mass Spectrometry
- 2D gel electrophoresis (2-DGE)
- Workflow of proteomics experiments (I)
- Tryptic digestion and desalting
- MALDI-TOF & Mascot
- Workflow Fingerprint (II) (Dutch)
- Workflow Fingerprint (II) (E)
- LC – MALDI - MS Coupling
- Nano LC in proteomic analysis
- New Workflows in Proteomics
- Water
- Synthetic Polymers
- Petrochemistry
- Introduction
- Process Micro GC
- Interview with Tim Lenior
- Introduction to Process Gas Chromatography
- Sample handling and integration back ground information
- Micro-process-gas-chromatography (µPGCs)
- Theory and research on µGC
- The available µGCs discussed
- Discussions and Conclusions
- The Shell middle distillate synthesis process (SMDS) process
- References
- Interview with Tim Lenior
- The Analytical lab in a broader perspective
- Gas Chromotography (GC)
- Data Analysis
- Quantifying Nature
- Qualitative Analysis
- Semimicro Analytical Techniques
- Characteristic Reactions of Select Metal Ions
- Characteristic Reactions of Antimony Ions (Sb³⁺)
- Characteristic Reactions of Aluminum Ions (Al³⁺)
- Characteristic Reactions of Ammonium Ion (NH₄⁺)
- Characteristic Reactions of Arsenic Ions (As³⁺)
- Characteristic Reactions of Barium (Ba²⁺)
- Characteristic Reactions of Bismuth (Bi³⁺)
- Characteristic Reactions of Cadmium Ions (Cd²⁺)
- Characteristic Reactions of Calcium Ions (Ca²⁺)
- Characteristic Reactions of Chromium Ions (Cr³⁺)
- Characteristic Reactions of Cobalt Ions (Co²⁺)
- Characteristic Reactions of Copper Ions (Cu²⁺)
- Characteristic Reactions of Iron (Fe³⁺)
- Characteristic Reactions of Lead Ions (Pb²⁺)
- Characteristic Reactions of Magnesium Ions (Mg²⁺)
- Characteristic Reactions of Manganese Ions (Mn²⁺)
- Characteristic Reactions of Mercury Ions (Hg²⁺ and Hg₂²⁺)
- Characteristic Reactions of Nickel Ions (Ni²⁺)
- Characteristic Reactions of Silver Ions (Ag⁺)
- Characteristic Reactions of Strontium Ions (Sr²⁺)
- Characteristic Reactions of Tin Ions (Sn²⁺, Sn⁴⁺)
- Characteristic Reactions of Zinc Ions (Zn²⁺)
- Properties of Select Nonmetal Ions
- Separations with Thioacetamide
- Confirmatory Tests
- Qualitative Analysis - Tests for Anions
- Qualitative Analysis - Tests for Cations
- Instrumental Analysis
- Chromatography
- Capillary Electrophoresis
- Countercurrent Separations
- Cyclic Voltammetry
- Mass Spectrometry
- Analytical Sciences Digital Library