4: Overview of Hemoglobin and Myoglobin
- Page ID
- 165282
\( \newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}} } \) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash {#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)\(\newcommand{\AA}{\unicode[.8,0]{x212B}}\)
- 4.1: Myoglobin, Hemoglobin, and their Ligands
- Hemoglobin and myoglobin have played important roles in the history of Biochemistry. They were the first proteins for which three -dimensional structures were determined by X-ray crystallography. Since then, these two proteins have been a valuable source of knowledge for many other proteins.
- 4.2: Oxygen Transport by the Proteins Myoglobin and Hemoglobin
- Cooperativity Enhances Oxygen Delivery by Hemoglobin. Because of cooperativity between O2-binding sites, hemoglobin delivers more O2 to tissues than would a noncooperative protein (pO2, partial pressure of oxygen.)
- 4.3: Exercises
- Almost all biochemistry textbooks start their description of the biological functions of proteins using the myoglobin and hemoglobin as exemplars. These are very rational approaches since they have become model systems to describe the binding of simple ligands, like dioxygen (O2), CO2, and H+, and how the structure of the protein determines and is influenced by binding of ligands.