Quantitative nuclear magnetic resonance (Q-NMR) measurements are especially useful for analysis of complex samples where high specificity is needed or when a pure standard of the analyte is not available. Often the sample can be analyzed with a minimum of preparation. Q-NMR has utility in various areas including:
- Purity analysis
- Food and wine quality analysis
- Impurity analysis
- Process monitoring
- Quality and degradation of pharmaceuticals
- Determination of enantiomeric excess
This text provides a brief overview of basic NMR theory, a tutorial discussing the practical aspects of Q-NMR, a virtual experiment utilizing an NMR simulator, an exercise that makes use of real NMR data you can download and analyze, and a Q-NMR lab experiment on the determination of malic acid in fruit juice. Several Q-NMR applications are highlighted and links to additional resources are provided along with a guide for instructors.