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Quantitative NMR (Larive and Korir)

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    Quantitative nuclear magnetic resonance (Q-NMR) measurements are especially useful for analysis of complex samples where high specificity is needed or when a pure standard of the analyte is not available. Often the sample can be analyzed with a minimum of preparation. Q-NMR has utility in various areas including:

    • Purity analysis
    • Food and wine quality analysis
    • Impurity analysis
    • Process monitoring
    • Quality and degradation of pharmaceuticals
    • Determination of enantiomeric excess

    This text provides a brief overview of basic NMR theory, a tutorial discussing the practical aspects of Q-NMR, a virtual experiment utilizing an NMR simulator, an exercise that makes use of real NMR data you can download and analyze, and a Q-NMR lab experiment on the determination of malic acid in fruit juice. Several Q-NMR applications are highlighted and links to additional resources are provided along with a guide for instructors.

    Quantitative NMR (Larive and Korir) is shared under a CC BY-NC-SA 2.5 license and was authored, remixed, and/or curated by Cynthia K. Larive & Albert K. Korir via source content that was edited to conform to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.