Skip to main content
Chemistry LibreTexts

Acid Anhydrides react with water to form carboxylic acids

  • Page ID
    5903
  • Acid Anhydrides react with water to form carboxylic acids

    General Reaction

    File:/C:\Users\Gantor\AppData\Local\Temp\msohtmlclip1\01\clip_image002.png

    Example 1:
    2.jpg

    Mechanism

    1) Nucleophilic Attack by the Alcohol

    File:/C:\Users\Gantor\AppData\Local\Temp\msohtmlclip1\01\clip_image006.png

    2) Deprotonation by pyridine

    File:/C:\Users\Gantor\AppData\Local\Temp\msohtmlclip1\01\clip_image008.png

    3) Leaving group removal

    File:/C:\Users\Gantor\AppData\Local\Temp\msohtmlclip1\01\clip_image010.png

    4) Protonation of the carboxylate

    File:/C:\Users\Gantor\AppData\Local\Temp\msohtmlclip1\01\clip_image012.png

    Contributors