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Acid Anhydrides React with Amines to Form Amides

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    • Acid Anhydrides react with amines to form amides

    General Reaction

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    Example 1:
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    Mechanism

    1) Nucleophilic Attack by the Amine

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    2) Deprotonation by the amine

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    3) Leaving group removal

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    Contributors

    Prof. Steven Farmer (Sonoma State University)

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