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2: Asymmetric Carbon-Carbon Bond Forming Reactions

Last updated

Mar 16, 2021
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- 1.5: Chiral Phosphoric Acids (PAs)
- 2.1: Enantioselective Ene and Cycloaddition Reactions

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2.1: Enantioselective Ene and Cycloaddition Reactions
Alder-ene and Diels-Alder reactions are six electron pericyclic processes between a “diene” or an alkene bearing an allylic hydrogen and an electron-deficient multiple bond to form two bonds σ with migration of the π bond. The lecture covers the examples of recent developments in enantioselective intermolecular Alder-ene glyoxylates with alkenes.
2.2: Enantioselective Alkene Metathesis
Among the alkene metathesis catalysts, Mo and Ru-based complexes have emerged as powerful exhibiting complementary reactivity and functional group tolerance. The asymmetric alkene metathesis provides access to enantiomerically enriched molecules that can not be generally prepared through the commonly practiced strategy.
2.3: Carbometallation and Carbocyclization Reactions
Organometallic compounds add to carbon-carbon multiple bonds to give a new organometallic species, which could be further modified to yield new carbon-carbon bonds. These processes are called as “carbometallation reactions”. It primarily refers to the relationship between the reactants and products. This section covers some examples of the asymmetric carbometallation reactions using Rh, Cu and Pd-based systems.
2.4: Metal-Catalyzed Asymmetric Conjugate Addition Reactions
2.5: Allylic Substitution with Carbon Nucleophiles
The metal-catalyzed allylic substitution is one most of the important processes in organic synthesis.
2.6: Problems and Reference

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