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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/02%3A_Asymmetric_Carbon-Carbon_Bond_Forming_Reactions/2.06%3A_Problems_and_ReferenceHow will you synthesis the following compounds using alkene metathesis? Give some examples of chiral Zr-catalyzed carbometallation reactions. Describe conjugate addition reactions using organocatalysi...How will you synthesis the following compounds using alkene metathesis? Give some examples of chiral Zr-catalyzed carbometallation reactions. Describe conjugate addition reactions using organocatalysis. Complete the following reactions. Predict the major product for the following reactions. Describe the chiral Fe, Ru, Ir and Rh-catalyzed asymmetric allylic alkylation reactions. Ojima, Catalytic Asymmetric Synthesis , 3 rd ed., Wiley, New Jersey, 2010.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/04%3A_Carbon-Heteroatom_Bond-Forming_ReactionsAsymmetric carbon-heteroatom bond formation is among the fundamentally important reactions. This module covers the carbon-heteroatom bond-forming reactions using transition-metal-complex as well as th...Asymmetric carbon-heteroatom bond formation is among the fundamentally important reactions. This module covers the carbon-heteroatom bond-forming reactions using transition-metal-complex as well as the chiral Lewis acid catalyzed protocols.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/12%3A_Solutions/12.01%3A_Asymmetric_Carbon-Carbon_Bond_Forming_Reactions
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/01%3A_Reactions_using_Chiral_Lewis_Acids_and_Brnsted_Acid/1.03%3A_LBA_CatalystsThe combination of Lewis acids and chiral Brønsted acids affords LBA catalysts. In this system, the coordination of the Lewis acids to the heteroatom of the chiral Brønsted acid results in increase th...The combination of Lewis acids and chiral Brønsted acids affords LBA catalysts. In this system, the coordination of the Lewis acids to the heteroatom of the chiral Brønsted acid results in increase the acidity of the latter.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/10%3A_Organocatalysis/10.03%3A_Thiourea_Based_CatalysisThe active site of the catalyst, the relevant stereoisomer of the imine substrate and the solution structure of the imine−catalyst complex are elucidated using kinetics, structural activity and NMR ex...The active site of the catalyst, the relevant stereoisomer of the imine substrate and the solution structure of the imine−catalyst complex are elucidated using kinetics, structural activity and NMR experiments. The deprotonation of the enol form of acetylacetone by the amine of the catalyst is found to occur easily, leading to an ion pair characterized by multiple H-bonds involving the thiourea unit as well.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/06%3A_Hydrogenation_Reactions/6.01%3A_Reactions_Carbon-Carbon_Double_BondsEnantioselective reduction of C=C double bonds have important applications in the synthesis of many natural products and pharmaceutically important compounds.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/02%3A_Asymmetric_Carbon-Carbon_Bond_Forming_Reactions/2.04%3A__Metal-Catalyzed_Asymmetric_Conjugate_Addition_ReactionsThis lecture covers some examples for the recent developments in the conjugate addition of Grignard, organozinc, organolithium, organocopper and organoborane reagents with activated alkenes in the pre...This lecture covers some examples for the recent developments in the conjugate addition of Grignard, organozinc, organolithium, organocopper and organoborane reagents with activated alkenes in the presence of chiral ligand or chiral catalysts. For example, the copper-catalyzed conjugate addition of dialkylzinc reagents to acyclic aliphatic α,β -unsaturated ketones proceed in the presence of L-9 with up to 94% ee, while the reaction using L-10 gives up to 98% ee (Scheme \(\PageIndex{8}\)).
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/04%3A_Carbon-Heteroatom_Bond-Forming_Reactions/4.03%3A_Hydroamination_of_AlkenesScandium 3,3'-tris(phenylsilyl)binaphtholate can be used as a highly active catalyst for the synthesis of pyrrolidine via intramolecular hydroamination (Scheme \(\PageIndex{1}\)). Scheme \(\PageIndex{...Scandium 3,3'-tris(phenylsilyl)binaphtholate can be used as a highly active catalyst for the synthesis of pyrrolidine via intramolecular hydroamination (Scheme \(\PageIndex{1}\)). Scheme \(\PageIndex{1}\) Chiral neutral zirconium amidate has been used for hydroamination of primary aminoalkenes with 93% ee (Scheme \(\PageIndex{1}\)). Scheme \(\PageIndex{2}\)
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/07%3A_Reactions_in_Nonconventional_Conditions/7.01%3A_Reactions_in_WaterMany of the organic solvents are volatile, flammable, sometimes explosive and have damaging effect to human health or on the environment. Thus, effort has been made to use nonconventional solvents whi...Many of the organic solvents are volatile, flammable, sometimes explosive and have damaging effect to human health or on the environment. Thus, effort has been made to use nonconventional solvents which are not only attractive from economical aspects, they can provide advantages of recovery and recyclability of the catalysts. The section covers the use of water, fluorous solvents, supercritical fluids and ionic liquids as nonconventional solvents.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/11%3A_Enzyme-Catalyzed_Asymmetric_Reactions/11.04%3A_Enantioselective_OxidationsIn this process, the reduced form of the cofactor (NADPH) is needed under the formation of NADP + that is in situ recycled using an enzymatic coupled cofactor reproduction. In this system, the oxidize...In this process, the reduced form of the cofactor (NADPH) is needed under the formation of NADP + that is in situ recycled using an enzymatic coupled cofactor reproduction. In this system, the oxidized form of the cofactor (NADP + ) is consumed in the initial ADH-catalyzed step, while the reduced form of the cofactor (NADPH) is then needed for the second, monooxygenase-catalyzed oxidation step.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/03%3A_Synthesis_via_C-H_Activation/3.02%3A_Reactions_With_Metal_Nitrenoid_and_Direct_C-H_OxidationThe nitrene insertion into C-H bonds provides powerful tool for the direct introduction of C-N bond from C-H bonds. The mechanism of metal nitrenoid formation is believed to take place via an in situ-...The nitrene insertion into C-H bonds provides powerful tool for the direct introduction of C-N bond from C-H bonds. The mechanism of metal nitrenoid formation is believed to take place via an in situ-formed iodonium ylide that produces the reactive metal nitrenoid intermediate in the presence of suitable metal.
