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18: Heteronuclear Multiple Quantum Coherence (HMQC)

18: Heteronuclear Multiple Quantum Coherence (HMQC)

Last updated

Nov 12, 2024
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- 17: Multinuclear Spin Over Half
- 19: HMBC

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Heteronuclear Correlations: HMQC*

One Bond Heteronuclear Correlations

Heteronuclear Multiple Quantum Coherence (and HSQC and Het-Cor) detect correlations between nuclei of two different types that are separated by one bond. This method gives one peak per each coupled pair. This technique is often used to identify which H is bonded to which C (or H-N).

In typical H-C HMQC, a ¹³C spectrum is displayed on f2 axis and a ¹H spectrum on the f1 axis. “Cross-peaks” show which hydrogens are attached to which carbons.

Typical tables show a letter assignment, the carbon shift, and then the shift of the hydrogen attached to that carbon.

	¹³C	¹H
a	10	0.9
b	28	1.5
c	43	2.6

*Spectra are simulated

HMQC of ethyl (E)-but-2-enoate

This is the HMQC spectrum of ethyl (E)-but-2-enoate

Label each of the C peaks with C_a, C_b, etc.
Determine which hydrogen is bonded to which carbon and indicate in the table provided.

¹³C Chemical Shift (ppm)	¹H Proton Shift (HMQC)
14
18
62
143
145
168

Draw Your Own HMQC

The ¹H and ¹³C of iodobutane are shown below:

Draw a predicted HMQC spectrum for this structure.

Lactone Carbon Assignments

Label the carbons from the HMQC Correlations for this structure.

Heteronuclear Correlations: HMQC*

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