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Chemistry LibreTexts

Acid Anhydrides React with Amines to Form Amides

Introduction

Acid Anhydrides react with amines to form amides

General Reaction

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Example 1: 
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Mechanism

1)   Nucleophilic Attack by the Amine

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2)  Deprotonation by the amine

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3) Leaving group removal

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Contributors

Prof. Steven Farmer (Sonoma State University)