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Acid Anhydrides react with alcohols to form esters

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    5904
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    Acid Anhydrides react with alcohols to form esters

    General Reaction

    Reactions of anhydrides use Pyridine as a solvent

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    Example 1:
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    Mechanism

    1)   Nucleophilic Attack by the Alcohol

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    2)  Deprotonation by pyridine

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    3) Leaving group removal

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     4)  Protonation of the carboxylate

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    Contributors

    Prof. Steven Farmer (Sonoma State University)