6: Carboxylic Acid Derivatives
- Page ID
- 469394
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The compounds discussed in this chapter are all considered to be derived from carboxylic acids, and include acid halides, acid anhydrides, esters and amides (thioesters and acyl phosphates are also briefly mentioned). As you proceed through the chapter, you should be looking for similarities in behaviour among the various classes of compounds. These similarities can be readily understood once you appreciate the fact that, in most of their reactions, carboxylic acid derivatives react via the nucleophilic acyl substitution mechanism.
- 6.4: Mixed Claisen Condensations
- Claisen condensations between different ester reactants are called Crossed Claisen reactions. Crossed Claisen reactions in which both reactants can serve as Claisen donors and Claisen acceptors generally give complex mixtures which are difficult to separate.