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Chemistry LibreTexts

Synthesis of Nitriles

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  • Amide to Nitrile Reduction
  • Preparation of Nitriles
    This page looks at various ways of making nitriles - from halogenoalkanes (haloalkanes or alkyl halides), from amides, and from aldehydes and ketones. It pulls together information from pages dealing with each of these kinds of compounds

Nitriles are formed by an SN2 reaction between a bromide and sodium cyanide

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1o Amides can be converted to nitriles by dehydration with thionyl chloride

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Addition of cyanide (-:C≡N) to an aldehyde or ketone forms a cyanohydrin

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Synthesis of Nitriles is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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