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Deuterium Exchange

Last updated

Jan 23, 2023
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- Claisen Reactions
- Enamine Reactions

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Due to the acidic nature of α hydrogens they can be exchanged with deuterium by reaction with D₂O (heavy water). The process is accelerated by the addition of an acid or base; an excess of D₂O is required. The end result is the complete exchange of all α hydrogens with deuterium.