Deuterium Exchange
- Page ID
- 1159
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Due to the acidic nature of α hydrogens they can be exchanged with deuterium by reaction with D2O (heavy water). The process is accelerated by the addition of an acid or base; an excess of D2O is required. The end result is the complete exchange of all α hydrogens with deuterium.
General reaction
Example 1: Deuterium Exchange
Mechanism in basic conditions
1) Enolate Formation
2) Deuteration
Problems
1) Please draw the product for the following reactions.
2) Answers
Contributors
- Prof. Steven Farmer (Sonoma State University)