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Negishi cross-coupling

  • Page ID
    15647
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    The Negishi reaction involves catalytic addition of alkylzinc nucleophiles to vinyl halides.

    negishi.gif

    Figure 1. The Negishi cross-coupling reaction.

    The proposed catalytic cycle for this reaction involves the crucial oxidative addition of the vinyl halide to the metal. The alkylzinc probably delivers the alkyl nucleophile to the metal via conventional nucleophilic substitution. Once both species are on the metal, they experience reductive elimination together.

    negishimech.gif

    Figure 2. Catalytic cycle for the Negishi cross-coupling reaction.


    Negishi cross-coupling is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

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