18e: Super Complex
- Page ID
- 150639
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Template:HideTOCElectron Transport:
Supercomplex I1III2IV1– A Multienzyme
Electron Pathway
- Fill in the blanks on the following statement:
In electron transport, the electrons from ____________ are transferred via complex I (NADH:ubiquinone oxidoreductase) and ubiquinone to complex _____ (ubiquinol:cytochrome c oxidoreductase). Thereafter they pass through cytochrome c to complex _____ (cytochrome c oxidase) to the terminal acceptor, ______________.
Multienzyme
In many organisms, this pathway is assembled into a supercomplex.
Schäfer, Dencher, Vonck and Parcej, Biochemistry, 2007, 46, 12579-12585.
- In terms of electron transfer rates and entropy, explain why is a supercomplex might be an advantage to an organism.
This is a 3D map of the Supercomplex I1III2IV1 along the membrane plane.
- Identify the three individual protein complexes:
- Complex I
- Complex III
- Complex IV
On the basis of the fitted structure, cytochromes b and c1 from complex III2 seem to face subunit II. Hence, the cytochrome c binding sites of both complexes are facing each other (shown below).
- Based on this picture of the supercomplex, speculate about the diffusion of the mobile electron carriers. How mobile are these carriers? Are the substrates directly channeled? Diffused over a short distance?