18a: Overview ETOP
- Page ID
- 150554
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Section: _____________________________
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Template:HideTOCStandard Reduction Potentials (E0'), 25oC
Oxidative Phosphorylation Overview
Overview
- Glycolysis (cytosol) and TCA cycle (mitochondria) convert glucose to high energy molecules: ________ and ___________ and __________.
This is just the beginning of energy production. NADH and FADH2 can be converted to more ATP. Oxidative phosphorylation is a metabolic pathway that transfers energy from NADH to the synthesis of ATP in the mitochondria.
- NADH oxidation occurs over many steps. Why don’t cells do this reaction directly? (Hint: This is a hydride reaction!)
Cellular Location
Electrons stored in the form of the reduced coenzymes, NADH or FADH2, are passed through a chain of proteins and coenzymes to reduce O2 – the terminal electron acceptor – into H2O.
- NADH is formed at what point in metabolism: ___________.
- The TCA cycle occurs in __________.
- This electron transfer of oxidative phosphorylation occurs in ________________.
ATP production
The energy released by electrons flowing through this electron transport chain is used to transport protons to generate a pH gradient across the membrane.
- The phosphorylation of ADP to form ATP is [endothermic or exothermic].
- Protons to flow back across the membrane to restore equilibrium. This process is [diffusion or active transport ] and can drive a reaction.