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Acid Anhydrides react with alcohols to form esters

Acid Anhydrides react with alcohols to form esters

General Reaction

Reactions of anhydrides use Pyridine as a solvent

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Example 1:
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Mechanism

1)   Nucleophilic Attack by the Alcohol

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2)  Deprotonation by pyridine

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3) Leaving group removal

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 4)  Protonation of the carboxylate

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Contributors

Prof. Steven Farmer (Sonoma State University)