Skip to main content
Chemistry LibreTexts

Reactivity of Amides

  • Page ID
    759
  • [ "article:topic-guide", "showtoc:no" ]

    Amides are reasonably reactive, usually via an attack on the carbonyl breaking the carbonyl double bond and forming a tetrahedral intermediate. Thiols, hydroxyls and amines are all known to serve as nucleophiles. Owing to their resonance stabilization, amides are less reactive under physiological conditions than esters.