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1° Amides can be converted to Nitriles with Thionyl Chloride

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    5892

    • 1o Amides can be converted to nitriles by reaction by dehydration with thionyl chloride.

    General reaction

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    Example 1:

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    Mechanism

    1) Nucleophilic attach on thionyl chloride

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    2) Leaving group removal

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    3) Deprotonation

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    4) Leaving group removal

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    Contributors

    Prof. Steven Farmer (Sonoma State University)