1° Amides can be converted to Nitriles with Thionyl Chloride
- Page ID
- 5892
1o Amides can be converted to nitriles by reaction by dehydration with thionyl chloride.
General reaction
Example 1: |
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Mechanism
1) Nucleophilic attach on thionyl chloride
2) Leaving group removal
3) Deprotonation
4) Leaving group removal
Contributors
Prof. Steven Farmer (Sonoma State University)