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Chemistry LibreTexts

20: Carboxylic Acid Derivatives and Nitriles

  • Page ID
    183120
  • learning objectives

    After reading this chapter and completing ALL the exercises, a student can be able to

    • describe the structure and physical properties of carboxylic acid derivatives and nitriles (section 22.1) 
    • determine the structure of carboxylic acid derivatives and nitriles from their elemental analysis and spectral data (MS, IR 1H NMR & 13C NMR) (section 22.2)
    • predict the products and specify the reagents to interconvert between a carboxylic acid and its derivatives  (section 22.3)
    • predict the products and specify the reagents to hydrolyze carboxylic acid derivatives (22.4)
    • predict the products and specify the reagents for transesterification reactions (section 22.5)
    • predict the products and specify the reagents for reduction reactions of carboxylic acid derivatives (section 22.6)
    • predict the products and specify the reagents for organometallic reactions with carboxylic acid derivatives (section 22.7)
    • predict the products and specify the reagents for the synthesis and reactions of
      • acyl chlorides (section 22.4)
      • anhydrides (section 22.5)
      • esters (section 22.6)
      • amides (section 22.7)
      • nitriles (section 22.8)
      • thioesters (section 22.9)
      • step-growth (condensation) polymers via ester and amide bonds (section 22.10)
    • discuss the chemistry of beta-lactams and biological acylation (section 22.11 and 22.12 respectively)
    • combine the reactions studied to date to develop efficient and effective multiple-step synthesis 

    Please note: IUPAC nomenclature and important common names of carboxylic acid derivatives and nitriles were explained in Chapter 3.