This page explains what amides are and looks at their simple physical properties such as solubility and melting points.
Amides are derived from carboxylic acids. A carboxylic acid contains the -COOH group, and in an amide the -OH part of that group is replaced by an -NH2 group. So, amides contain the -CONH2 group. The most commonly discussed amide is ethanamide, CH3CONH2 (old name: acetamide).
The three simplest amides are:
Notice that in each case, the name is derived from the acid by replacing the "oic acid" ending by "amide". If the chain were branched, the carbon in the -CONH2 group counts as the number 1 carbon atom. For example:
Methanamide is a liquid at room temperature (melting point: 3°C), but the other amides are solid. For example, ethanamide forms colorless deliquescent crystals with a melting point of 82°C. A deliquescent substance absorbs water from the atmosphere and then dissolves in it. Ethanamide crystals nearly always look wet.
The melting points of the amides are high for the size of the molecules because they can form hydrogen bonds. The hydrogen atoms in the -NH2 group are sufficiently positive to form a hydrogen bond with a lone pair on the oxygen atom of another molecule.
As you can see, there is the potential for lots of hydrogen bonds to be formed. Each molecule has two slightly positive hydrogen atoms and two lone pairs on the oxygen atom. These hydrogen bonds need a reasonable amount of energy to break, and so the melting points of the amides are quite high.
Solubility in water
The small amides are soluble in water because they have the ability to hydrogen bond with the water molecules. It needs energy to break the hydrogen bonds between amide molecules and between water molecules before they can mix - but enough energy is released again when the new hydrogen bonds are set up to allow this to happen.
Jim Clark (Chemguide.co.uk)