Acid chlorides react with ammonia, 1° amines and 2° amines to form amides
- Page ID
- 5956
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Acid chlorides react with ammonia, 1o amines and 2o amines to form amides.
General Reaction
Examples:
Mechanism
1) Nucleophilic attack by the amine
2) Leaving group is removed
3) Deprotonation
Contributors
Prof. Steven Farmer (Sonoma State University)