Acid chlorides react with ammonia, 1° amines and 2° amines to form amides

Acid chlorides react with ammonia, 1^o amines and 2^o amines to form amides.

General Reaction

Examples:

Mechanism

1) Nucleophilic attack by the amine

2) Leaving group is removed

3) Deprotonation

Contributors

Prof. Steven Farmer (Sonoma State University)