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Acid chlorides react with ammonia, 1° amines and 2° amines to form amides

  • Page ID
    5956
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    Acid chlorides react with ammonia, 1o amines and 2o amines to form amides.

    General Reaction

    OrganicCore_AcidHalides14.png

    Examples:

    OrganicCore_AcidHalides15.png

    Mechanism

    1) Nucleophilic attack by the amine

    OrganicCore_AcidHalides16.png

     

    2) Leaving group is removed

    OrganicCore_AcidHalides17.png

     

    3) Deprotonation

    OrganiCore_AcidHalides18.png

     

    Contributors

    Prof. Steven Farmer (Sonoma State University)


    Acid chlorides react with ammonia, 1° amines and 2° amines to form amides is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

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