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3: Synthesis via C-H Activation
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3.1: Reactions with Metal Carbenoid
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Functionalization of C-H bonds constitutes an attractive approach for the direct synthesis of complex organic molecules such as pharmaceuticals, natural products, and other industrially relevant targets. Two major directions evolved for the C-H functionalization process are (i) direct C-H activation involving oxidative addition to the C-H bond onto an active metal center, and (ii) insertion of transition metal-coordinated carbenes or nitrenes into the C-H bond to give functionalized products.
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3.2: Reactions With Metal Nitrenoid and Direct C-H Oxidation
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The nitrene insertion into C-H bonds provides powerful tool for the direct introduction of C-N bond from C-H bonds. The mechanism of metal nitrenoid formation is believed to take place via an in situ-formed iodonium ylide that produces the reactive metal nitrenoid intermediate in the presence of suitable metal.
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3.3: Problems and Reference
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