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1.2: Safety

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    NOTES: The first use of a chemical is designated in the procedure with an asterisk. Additional information about the chemicals will be found in Appendix A.

    The organic liquids used in quantity in this experiment: dimethyl sulfoxide, dimethoxyethane, cyclopentadiene, and dicyclopentadiene are volatile and possess noxious vapors. Avoid inhalation. Carry out operations with these organic liquids in the hood.

    1. Dicyclopentadiene: Noxious liquid. Handle with usual caution: do not ingest. If it is spilled on skin, rinse well with water.
    2. Potassium hydroxide (KOH): Very caustic chemical. Handle with caution and keep away from skin and clothing. If it spills, wash well with soap and rinse with plenty of water.
    3. Iron Chloride (FeCl2•4H2O): Ferrous salts can be toxic. Handle with usual caution: do not ingest.
    4. Dimethyl sulfoxide [DMSO, (CH3)2SO]: Not considered toxic. However, it increases the permeability of the skin to other substances. Therefore, it may render other chemicals more hazardous by allowing entry through the natural skin barrier. Substances ordinarily regarded as harmless on the skin can become dangerous when the nonpermeability of the skin has been altered by application of DMSO. If DMSO is spilled, wash well with soap and plenty of water.
    5. Hydrochloric acid (HCl): Very acidic liquid. Contact with skin will cause burns. If any gets on you or your clothing, remove affected clothing, rinse immediately with water.
    6. Acetone (CH3COCH3): acetone is an organic solvent and should be treated with normal caution: keep away from flames and dispose as organic waste. It has the ability to increase the permeability of skin and should not be spilled on hands, etc.
    7. Phosphoric acid (H3PO4): Concentrated solutions are irritating to the skin and mucous membranes. Essentially nontoxic, the compound is used to flavor foods and for many other commercial applications.
    8. Acetic anhydride [(CH3CO)2O]: Combustible organic liquid. Strong acetic odor. Reacts with alcohol to form ethyl acetate, water to form acetic acid. Avoid contact with skin and eyes, as the compound produces irritation and necrosis of tissues.
    9. Methylene chloride (CH2Cl2): Common organic solvent. It is flammable and volatile. Prolonged exposure causes liver damage. Use in the hood; avoid prolonged breathing of vapor. If spilled soak up with vermiculite and dispose of as organic waste.
    10. Hexane (C6H14), ethyl acetate (CH3CO2C2H5), dimethoxyethane (CH3OCH2CH2OCH3): Common organic solvents handle accordingly: keep away from flames, do not ingest or inhale, dispose of as organic waste.
    11. Chloroform (CHCl3): Properties similar to methylene chloride, handle accordingly. Suspected carcinogen.
    12. Alumina (Al2O3): Common chromatographic support. It is not considered hazardous except when inhaled or ingested in large quantities.
    13. Ferrocene (( η5 -C5H5)2Fe): An organometallic compound of moderate toxicity. Handle with the usual caution. Prevent ingestion, inhalation and skin contact. Chronic exposure may cause liver damage. Heating to decomposition emits acrid smoke, irritating fumes.
    14. Acetylferrocene ((η5 -C5H5)Fe(η5 -C5H4(COCH3))): Highly toxic organometallic compound. Handle with caution. Prevent ingestion, inhalation and skin contact. Heating to decomposition emits acrid smoke, irritating fumes.

    1.2: Safety is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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