Skip to main content
Chemistry LibreTexts

Acid chlorides react with ammonia, 1° amines and 2° amines to form amides

Acid chlorides react with ammonia, 1amines and 2o amines to form amides.

General Reaction

 

Examples:

Mechanism

1)   Nucleophilic attack by the amine

 

2) Leaving group is removed

 

3) Deprotonation

 

Contributors

Prof. Steven Farmer (Sonoma State University)