40: Toxicology MSDT
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One of the challenges of recruiting undergraduates into the toxicology graduate research programs is a lack toxicology training programs and courses at the undergraduate level. Course content developed through this program are accessible to the general public. The intent is to provide content where other undergraduate students, K-12 educators, and the interested public encounter content providing an introduction to the discipline of toxicology.
- 40.1: Pathophysiology
- Pathophysiology is the study of the physical and functional changes that occur during a disease process. In this e-module you will learn about the concept of pathophysiology, types of toxicity, repair and adaptation, and patterns of toxic injury.
- 40.2: Biochemistry and Molecular Genetics
- Biochemistry is the study of chemical processes within and related to living organisms. In this e-module you will learn about biomolecules and cell components, cell structure and subcellular compartments, DNA and RNA metabolism, and epigenetic mechanisms.
- 40.3: Principles of Genetic Toxicology
- The genetic toxicology methodology or assay technique helps to test or evaluate the level of damages of the genetic information caused by toxicants or agents within the cells. In this e-module you will learn about different genetic toxicology assays, different genetic damages, and cytotoxicity and epigenetics assays.
- 40.4: Applied Systems Toxicology
- Systems toxicology is a branch of science that utilizes data from different branches of toxicology and integrates them to provide a holistic approach for safety assessment. In this e-module you will learn about the concept of systems toxicology, dose level in toxicology, and different approaches to traditional and new toxicology.
- 40.5: Regulatory Toxicology
- Regulatory toxicology is where the science of toxicology meets the regulations, policies and guidelines that protect human health and the environment from chemicals. In this e-module you will learn about global, regional, national, state, and non-governmental regulatory toxicology.
- 40.6: Principles of Toxicology
- 40.6.1: Introduction to Toxicology
- 40.6.1.1: What is toxicology?
- 40.6.1.2: Basic Terminology
- 40.6.2: Dose and Dose Response
- 40.6.2.1: Dose and It's Impact on Toxicity
- 40.6.2.2: The Dose Response Relationship
- 40.6.2.3: Dose Estimates of Toxic Effects
- 40.6.2.4: Determining the Safety of a Drug
- 40.6.2.5: NOAEL and LOAEL
- 40.6.3: Toxic Effects
- 40.6.3.1: Types of Toxic Effects
- 40.6.3.2: Factors Affecting Toxicity
- 40.6.3.3: Systemic Toxic Effects
- 40.6.3.4: Organ Specific Toxic Effects
- 40.6.4: Interactions
- 40.6.4.1: Interactions
- 40.6.5: Toxicity Testing Methods
- 40.6.5.1: Testing and Assessing Toxicity
- 40.6.5.2: Clinical Investigations and Other Types of Human Data
- 40.6.5.3: Epidemiology Studies
- 40.6.6: Risk Assessment
- 40.6.6.1: Risk Assessment
- 40.6.6.2: Hazard Identification
- 40.6.6.3: Dose-Response Assessment
- 40.6.6.4: Exposure Assessment
- 40.6.6.5: Risk Characterization
- 40.6.7: Exposure Standards and Guidelines
- 40.6.7.1: Exposure Standards and Guidelines
- 40.6.7.2: Regulation of Consumer Products and Drug Safety
- 40.6.7.3: Environmental Exposure Standards/Guidelines
- 40.6.7.4: Occupational (Workplace) Exposure Standards/Guidelines/Approaches
- 40.6.8: Basic Physiology
- 40.6.8.1: Introduction to Basic Physiology
- 40.6.8.2: Homeostasis
- 40.6.8.3: Organs and Organ Systems
- 40.6.8.4: Tissues
- 40.6.8.5: Cells
- 40.6.8.6: Chemicals
- 40.6.9: Introduction to Toxicokinetics
- 40.6.9.1: What is Toxicokinetics
- 40.6.10: Absorption
- 40.6.10.1: Introduction to Absorption
- 40.6.10.2: Gastrointestinal Tract
- 40.6.10.3: Respiratory Tract
- 40.6.10.4: Dermal Route
- 40.6.10.5: Other Routes of Exposure
- 40.6.11: Distribution
- 40.6.11.1: Introduction to Distribution
- 40.6.11.2: Influence of Route of Exposure
- 40.6.11.3: Disposition Models
- 40.6.11.4: Structural Barriers to Distribution
- 40.6.11.5: Storage Sites
- 40.6.12: Biotransformation
- 40.6.12.1: Introduction to Biotransformation
- 40.6.12.2: Chemical Reactions
- 40.6.12.3: Biotransformation Sites
- 40.6.12.4: Modifiers of Biotransformation
- 40.6.13: Excretion
- 40.6.13.1: Introduction to Secretion
- 40.6.13.2: Urinary Excretion
- 40.6.13.3: Fecal Excretion
- 40.6.13.4: Exhaled Air
- 40.6.13.5: Other Routes
- 40.6.14: Cellular Toxicology
- 40.6.14.1: Adaptation
- 40.6.14.2: Cell Damage and Tissue Repair
- 40.6.14.3: Cancer
- 40.6.14.4: Neurotoxicity
- 40.6.15: Intuitive Toxicology and Risk Communication
- 40.6.15.1: Intuitive Toxicology
- 40.6.15.2: Risk Communication
- 40.6.16: Environmental Toxicology, Environmental Health, and One Health
- 40.6.16.1: Environmental Toxicology
- 40.6.16.2: Environmental Health
- 40.6.16.3: One Health
- 40.6.17: Conclusion