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Hofmann rearrangement

Last updated

Jan 23, 2023
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- Hofmann Elimination
- Horner-Wadsworth-Emmons Reaction

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Hofmann rearrangement, also known as Hofmann degradation and not to be confused with Hofmann elimination, is the reaction of a primary amide with a halogen (chlorine or bromine) in strongly basic (sodium or potassium hydroxide) aqueous medium, which converts the amide to a primary amine. For example:

Mechanism:

Contributors

Gamini Gunawardena from the OChemPal site (Utah Valley University)

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