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- https://chem.libretexts.org/Courses/Los_Angeles_Trade_Technical_College/Analytical_Chemistry/2%3A_Analytical_Chemistry_2.0_(Harvey)/04%3A_The_Vocabulary_of_Analytical_Chemistry/4.4%3A_Selecting_an_Analytical_MethodA method is the application of a technique to a specific analyte in a specific matrix. We can develop an analytical method for determining the concentration of lead in drinking water using any of the ...A method is the application of a technique to a specific analyte in a specific matrix. We can develop an analytical method for determining the concentration of lead in drinking water using any of the techniques mentioned in the previous section. The requirements of the analysis determine the best method and consideration is given the following criteria: accuracy, precision, sensitivity, selectivity, robustness, ruggedness, scale of operation, analysis time, availability of equipment, and cost.
- https://chem.libretexts.org/Courses/Los_Angeles_Trade_Technical_College/Analytical_Chemistry/2%3A_Analytical_Chemistry_2.0_(Harvey)/15%3A_Developing_a_Standard_Method/15.2%3A_Verifying_the_MethodAfter developing and optimizing a method, the next step is to determine how well it works in the hands of a single analyst. Three steps make up this process: determining single-operator characteristic...After developing and optimizing a method, the next step is to determine how well it works in the hands of a single analyst. Three steps make up this process: determining single-operator characteristics, completing a blind analysis of standards, and determining the method’s ruggedness. If another standard method is available, then we can analyze the same sample using both methods and compare the results. If the result for any single test is unacceptable, then the method is not a suitable.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/14%3A_Developing_a_Standard_Method/14.02%3A_Verifying_the_MethodThe page outlines the process of determining a method's effectiveness in a single-analyst scenario, involving the evaluation of precision, accuracy, and detection limits through single-operator charac...The page outlines the process of determining a method's effectiveness in a single-analyst scenario, involving the evaluation of precision, accuracy, and detection limits through single-operator characteristics, blind analysis, and ruggedness testing. It highlights the comparison of new and standard methods and describes ruggedness testing through experimental design to assess variability factors.
- https://chem.libretexts.org/Courses/Lakehead_University/Analytical_I/4%3A_Evaluating_Analytical_Data/4.07%3A_Detection_LimitsA method’s detection limit as the smallest concentration or absolute amount of analyte that has a signal significantly larger than the signal from a suitable blank. Although our interest is in the amo...A method’s detection limit as the smallest concentration or absolute amount of analyte that has a signal significantly larger than the signal from a suitable blank. Although our interest is in the amount of analyte, in this section we will define the detection limit in terms of the analyte’s signal.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/03%3A__The_Vocabulary_of_Analytical_Chemistry/3.10%3A_Chapter_Summary_and_Key_TermsThe chapter emphasizes the importance of mastering the vocabulary specific to analytical chemistry, differentiating terms such as analyte, matrix, technique, method, procedure, and protocol. It discus...The chapter emphasizes the importance of mastering the vocabulary specific to analytical chemistry, differentiating terms such as analyte, matrix, technique, method, procedure, and protocol. It discusses key criteria for selecting analytical methods, including accuracy, precision, sensitivity, and more, highlighting the need to balance these interdependent factors.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/04%3A_Evaluating_Analytical_Data/4.07%3A_Detection_LimitsThe page discusses the IUPAC's definition of a method's detection limit as the smallest signal indicating the presence of an analyte, distinct from a blank signal. It delves into statistical concepts ...The page discusses the IUPAC's definition of a method's detection limit as the smallest signal indicating the presence of an analyte, distinct from a blank signal. It delves into statistical concepts like type 1 and type 2 errors, explaining the probability associated with detecting an analyte.
- https://chem.libretexts.org/Courses/Los_Angeles_Trade_Technical_College/Analytical_Chemistry/2%3A_Analytical_Chemistry_2.0_(Harvey)/16%3A_Quality_Assurance/16.4%3A_Evaluating_Quality_Assurance_DataNow we turn our attention to how we incorporate this quality assessment data into a complete quality assurance program. There are two general approaches to developing a quality assurance program: a pr...Now we turn our attention to how we incorporate this quality assessment data into a complete quality assurance program. There are two general approaches to developing a quality assurance program: a prescriptive approach, in which we prescribe an exact method of quality assessment, and a performance-based approach in which we can use any form of quality assessment, provided that we can demonstrate an acceptable level of statistical control.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/15%3A_Quality_Assurance/15.05%3A_ProblemsThis page contains instructions related to various analytical chemistry tasks and practices, including developing lab guidelines, conducting specific measurements, analyzing limits of detection, calcu...This page contains instructions related to various analytical chemistry tasks and practices, including developing lab guidelines, conducting specific measurements, analyzing limits of detection, calculating statistical values such as standard deviations, creating control charts, and evaluating spike recoveries.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/03%3A__The_Vocabulary_of_Analytical_Chemistry/3.06%3A_ProtocolsA protocol is a set of stringent written guidelines crucial for agency approval of analytical results. It includes procedures for internal and external QA/QC to ensure accuracy. The EPA's protocol for...A protocol is a set of stringent written guidelines crucial for agency approval of analytical results. It includes procedures for internal and external QA/QC to ensure accuracy. The EPA's protocol for trace metal analysis using atomic absorption spectroscopy involves calibration with a method blank and three standards. Calibration is verified through ICV and ICB samples, needing results within ??10% accuracy.
- https://chem.libretexts.org/Courses/Lakehead_University/Analytical_I/3%3A_The_Vocabulary_of_Analytical_Chemistry/3.4%3A_Selecting_an_Analytical_MethodA method is the application of a technique to a specific analyte in a specific matrix. We can develop an analytical method for determining the concentration of lead in drinking water using any of the ...A method is the application of a technique to a specific analyte in a specific matrix. We can develop an analytical method for determining the concentration of lead in drinking water using any of the techniques mentioned in the previous section. The requirements of the analysis determine the best method and consideration is given the following criteria: accuracy, precision, sensitivity, selectivity, robustness, ruggedness, scale of operation, analysis time, availability of equipment, and cost.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Instrumental_Analysis_(LibreTexts)/01%3A_Introduction/1.04%3A_Selecting_an_Analytical_MethodChoosing an analytical method requires matching the method's strengths and weaknesses—its performance characteristics—to the needs of your analysis.
