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Chemistry LibreTexts

9.2.2: Steroids

  • Page ID
    209642
  • Learning Objectives

    • To identify the functions of steroids produced in mammals.

    All the lipids discussed so far are saponifiable, reacting with aqueous alkali to yield simpler components, such as glycerol, fatty acids, amino alcohols, and sugars. Lipid samples extracted from cellular material, however, also contain a small but important fraction that does not react with alkali. The most important nonsaponifiable lipids are the steroids. These compounds include the bile salts, cholesterol and related compounds, and certain hormones (such as cortisone and the sex hormones).

    clipboard_e774c891d65106cfde47c8763bc77c0b8.png
    Figure \(\PageIndex{1}\) Steroids. (a) The four-fused-ring steroid skeleton uses letter designations for each ring and the numbering of the carbon atoms. (b) The cholesterol molecule follows this pattern.

    Steroids occur in plants, animals, yeasts, and molds but not in bacteria. They may exist in free form or combined with fatty acids or carbohydrates. All steroids have a characteristic structural component consisting of four fused rings. Chemists identify the rings by capital letters and number the carbon atoms as shown in Figure \(\PageIndex{1a}\). Slight variations in this structure or in the atoms or groups attached to it produce profound differences in biological activity.

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