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22.0 Introduction

  • Page ID
    91004
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    Objectives

    After completing this section, you should be able to write a general mechanism for an alpha‑substitution reaction of a carbonyl compound.

    Key Terms

    Make certain that you can define, and use in context, the key terms below.

    • alpha (α) position
    • alpha‑substitution reaction
    Study Notes

    An “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. Attack by the electrophile (E+) can occur on the enol or enolate intermediate.

    alpha substitution reaction through enol and enolate intermdediates

    Contributors and Attributions

    Dr. Dietmar Kennepohl FCIC (Professor of Chemistry, Athabasca University)


    22.0 Introduction is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

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