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Chemistry LibreTexts

20: Amines

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  • learning objectives

    After reading this chapter and completing ALL the exercises, a student can be able to

    • describe the structure and physical properties of amines and ammonium salts (section 20.1)
    • explain and predict the relative basicity of amines using resonance, hybridization, substituent effects, and aromaticity (section 20.2)
    • determine the structure of amines from their elemental analysis and spectral data (MS, IR 1H NMR & 13C NMR) (section 20.3)
    • predict the products and specify the reagents to synthesize amines (section 20.4)
    • predict the products and specify the reagents to synthesize primary amines (section 20.5)
    • predict the products and specify the reagents for reactions of amines with
      • aldehydes & ketones (section 20.6)
      • alkyl halides and tosylates (section 20.6)
      • acyl chlorides (section 20.6)
      • sulfonyl chlorides (section 20.6)
      • nitrous acid (section 20.7)
      • oxidizing agents via Cope Elimination (section 20.9)
    • explain the activating effects of aryl amines during electrophilic aromatic substitution reactions (section 20.7)
    • use amides as protecting groups in multiple step synthesis (section 20.7)
    • use diazonium salts to design multiple step syntheses using the Sandmeyer reactions (section 20.7)
    • specify the reagents and predict the products for Hofmann Elimination reactions (section 20.8)
    • Specify reagents for chemical transformations using all of the reactions studied to date
    • combine the reactions studied to date to develop efficient and effective multiple-step synthesis including the use of amides as protecting groups

    Please note: IUPAC nomenclature and important common names of amines were explained in Chapter 3.