5: Structure Reactivity Relationships
- Page ID
- 401817
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- 5.1: Correlations of Structure with Reactivity of Aromatic Compounds
- This section is concerned with the quantitative correlation of reaction rates and equilibria of organic reactions with the structure of the reactants. We will restrict the discussion to benzene derivatives. The focus is on a remarkably simple treatment developed by L. P. Hammett in 1935, which has been tremendously influential. Hammett's correlation covers chemical reactivity, spectroscopy and other physical properties, and even the biological activity of drugs.