Section 9: Introduction to Toxicokinetics
- Page ID
- 316741
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Learning Objectives
After completing this lesson, you will be able to:
- Define toxicokinetics.
- Summarize the four inter-related processes of toxicokinetics.
- Identify examples of transporter proteins and their role in toxicokinetics.
What We've Covered
This section made the following main points:
- Toxicokinetics is essentially the study of how a substance enters the body and what happens to it inside the body.
- The term "disposition" is often used in place of toxicokinetics to describe how the body disposes of a xenobiotic over time.
- The four inter-related processes of toxicokinetics are:
- Absorption — the substance enters the body.
- Distribution — the substance moves from the site of entry to other areas of the body.
- Biotransformation — the substance is transformed into new chemicals (metabolites).
- Excretion — the substance or its metabolites leave the body.
- The disposition of a toxicant and its biological reactivity are the factors that determine the severity of toxicity when a xenobiotic enters the body.