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Nucleophilic Aromatic Substitution

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  • A nucleophilic aromatic substitution is a nucleophilic substitution reaction in which it is a leaving group on an aromatic ring that is replaced by the nucleophile.

    eg. 1:

    net reaction:

    eg. 2:

    net reaction:

    see also benzyne mechanism, SNAr mechanism, nucleophilic aliphatic substitution

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