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Mannich Base

Last updated

Sep 3, 2016
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- Malonic Ester Synthesis
- Mannich Reaction

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The acid-catalyzed reaction of an enolizable aldehyde or an enolizable ketone with an imminium ion, usually generated in situ by the reaction of formaldehyde with a secondary amine, followed by a base to give a β-aminoaldehyde of a β-aminoketone, respectively, is known as the Mannich reaction. The product of the Mannich reaction is called the Mannich base.

eg:

mechanism:

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