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Chemistry LibreTexts

Hofmann Rule

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  • Hofmann rule is an empirical rule used to predict regioselectivity of 1,2-elimination reactions occurring via E1cB mechanism. It states that, in a regioselective E1cB reaction, the major product is the less stable alkene, i.e., the alkene with the less highly substituted double bond. For example see Hofmann elimination.

    see also Zaitsev’s Rule