Hofmann Rule
( \newcommand{\kernel}{\mathrm{null}\,}\)
Hofmann rule is an empirical rule used to predict regioselectivity of 1,2-elimination reactions occurring via E1cB mechanism. It states that, in a regioselective E1cB reaction, the major product is the less stable alkene, i.e., the alkene with the less highly substituted double bond. For example see Hofmann elimination.
see also Zaitsev’s Rule