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Friedel-Crafts Acylation

  • Page ID
    40376
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    Friedel-Crafts acylation is the reaction of benzene and substituted benzenes with acid chlorides in the presence of a Lewis acid catalyst. The net reaction is an electrophilic aromatic substitution.

    eg:

    friedelcraftsacylation1.png

    net reaction:

    friedelcraftsacylation2.png

    mechanism:

    friedelcraftsacylation3.png

    Step 1:

    friedelcraftsacylation4.png

    Step 2:

    friedelcraftsacylation5.png

    see also acylium ion, Friedel-Crafts alkylation, Fries rearrangement


    Friedel-Crafts Acylation is shared under a All Rights Reserved (used with permission) license and was authored, remixed, and/or curated by Gamini Gunawardena via source content that was edited to conform to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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