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Crossed Aldol Reaction

Last updated

Feb 28, 2022
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- Crossed Aldol Condensation
- Crossed Claisen Condensation

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Crossed aldol reaction is a variation of aldol reaction.

aldol reaction:

crossed aldol reaction:

eg:

Mechanism:
Step 1: The hydroxide ion deprotanates the enolizable aldehyde reversibly.

Step 2: Enolate ion 1 preferentially adds to the non-enolizable aldehyde, which has the sterically less hindered and, therefore, more accessible carbonyl carbon.

Step 3: Alkoxide ion 2 is protonated by water.

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