Skip to main content
Chemistry LibreTexts

Crossed Aldol Reaction

[ "article:topic", "authorname:ggunawardena" ]
  • Page ID
    39391
  •  

    Crossed aldol reaction is a variation of aldol reaction.

    aldol reaction:

     

     

    crossed aldol reaction:

     

     

    eg:

     

     

    Mechanism:
    Step 1:  The hydroxide ion deprotanates the enolizable aldehyde reversibly.

     

     

    Step 2:  Enolate ion 1 preferentially adds to the non-enolizable aldehyde, which has the sterically less hindered and, therefore, more accessible carbonyl carbon.

     

     

    Step 3:  Alkoxide ion 2 is protonated by water.

     

     

    see also crossed aldol condensation