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10.9: Introduction to Toxicokinetics

Last updated

Jul 30, 2024
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- 10.8.6: Chemicals
- 10.9.1: What is Toxicokinetics

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Learning Objectives

After completing this lesson, you will be able to:

Define toxicokinetics.
Summarize the four inter-related processes of toxicokinetics.
Identify examples of transporter proteins and their role in toxicokinetics.

In this section...

Topics include:

10.9.1: What is Toxicokinetics

What We've Covered
This section made the following main points:

Toxicokinetics is essentially the study of how a substance enters the body and what happens to it inside the body.
- The term "disposition" is often used in place of toxicokinetics to describe how the body disposes of a xenobiotic over time.
The four inter-related processes of toxicokinetics are:
1. Absorption — the substance enters the body.
2. Distribution — the substance moves from the site of entry to other areas of the body.
3. Biotransformation — the substance is transformed into new chemicals (metabolites).
4. Excretion — the substance or its metabolites leave the body.
The disposition of a toxicant and its biological reactivity are the factors that determine the severity of toxicity when a xenobiotic enters the body.

Learning Objectives

In this section...

What We've Covered This section made the following main points:

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What We've Covered
This section made the following main points: