1.24: Bone Disease
- Page ID
- 125336
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- The most active form of Vitamin D is 1, 25 dihydroxycholecalciferol, and this final hydroxylation takes place in:
- skin
- liver
- kidney
- skin and liver
- liver and kidney
- Which of the following changes in serum analyte concentration are associated with hypercalcemia and hyperparathyroidism?:
- low phosphorous, and low Vitamin D3
- high phosphorous, and low Vitamin D3
- low phosphorous, and high Vitamin D3
- high phosphorous, and high Vitamin D3
- normal phosphorous and Vitamin D3
- Which of the following changes in serum analytes are associated with rickets and Vitamin D deficiency?:
- low calcium, and low phosphorous
- low calcium, and high phosphorous
- high calcium, and low phosphorous
- high calcium, and high phosphorous
- calcium and phosphorous normal
- Osteoporosis can be differentiated from osteomalacia by which of the following combinations of serum analyte levels?:
- low Ca, normal P, high alkaline phosphatase
- high Ca, normal P, low alkaline phosphatase
- high Ca, high P, normal alkaline phosphatase
- normal Ca, normal P, high alkaline phosphatase
- normal Ca, normal P, normal alkaline phosphatase
- The best biochemical marker of bone turnover is:
- Urine hydroxyproline
- Serum osteocalcin
- Serum bone alkaline phosphatase
- Urine \(\gamma\)-carboxyglutamic acid
- Urine N-terminal teleopeptides
- Peak bone mass is the:
- Maximum bone mass attained by a fetus
- Maximum bone mass attained by an individual
- Not affected by genetics of environmental factors
- Maximum bone mass attained by postmenopausal women
- Maximum bone quality achieved in puberty
- Which of the following treatments does not increase the risk for secondary osteoporosis?
- Chronic glucocorticoid therapy
- Methotrexate
- Insulin
- Cyclosporin A
- Long-term treatment with phenobarbital or phenytoin.
Use the following Key to answer Questions 8-13:
- 1, 2, and 3 are correct
- 1 and 3 are correct
- 2 and 4 are correct
- only 4 is correct
- all are correct
- Which of the following are causes of hypermagnesemia?:
- magnesium sulfate therapy
- magnesium-continuing antacids
- renal failure
- thyrotoxicosis
- The primary target organs for Vitamin D3 action are:
- kidney
- intestine
- bone
- parathyroid gland
- Which of the following changes are associated with renal parenchymal disease?:
- decreased serum calcium
- increased parathyroid hormone
- decreased calcitriol synthesis
- decreased serum phosphorous concentration
- Which of the following are important in regulating plasma calcium levels?
- parathyroid hormone (PTH)
- calcitonin
- 1, 25, dihydroxyvitamin D3
- aldosterone
- Which of the following factors are determinants of bone health?
- Nutritional
- Gonadal steroids
- Exercise
- Environmental lifestyle factors
- Osteoperosis is primarily a disease of:
- Infants
- Postmenopausal women
- Former athletes
- Men and women older than 70 years
- Answer
-
- c (p. 513)
- c (p. 525, 527)
- a (p. 522-523)
- e (p. 517)
- e (p. 510-511)
- b (p. 508-509)
- a (p. 524)
- a (p. 513,514, 516)
- e (p. 511-512)
- c (p. 518, 520)