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- https://chem.libretexts.org/Courses/Martin_Luther_College/Organic_Chemistry_-_MLC/03%3A_Alcohols_Ethers_Thiols_Sulfides_and_Amines/3.03%3A_Amines_and_Heterocycles/3.3.03%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/10%3A_Amines_and_Heterocycles/10.07%3A_Synthesis_of_AminesThe Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid ...The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 ) There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/24%3A_Amines_and_Heterocycles/24.07%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Courses/University_of_Connecticut/Chem_2444%3A_(Second_Semester_Organic_Chemistry)_UConn/11%3A_Chemistry_of_Amines/11.05%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_III_(Morsch_et_al.)/24%3A_Amines_and_Heterocycles/24.06%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/24%3A_Amines_and_Heterocycles/24.07%3A_Synthesis_of_AminesAn imine intermediate is first formed by a nucleophilic addition reaction (Section 19.8), and the C═N C═N bond of the imine is then reduced to the amine, much as the C═O C═O bond of a ketone can be re...An imine intermediate is first formed by a nucleophilic addition reaction (Section 19.8), and the C═N C═N bond of the imine is then reduced to the amine, much as the C═O C═O bond of a ketone can be reduced to an alcohol. Thus, the bromination of an amide in steps 1 and 2 is analogous to the base-promoted bromination of a ketone enolate ion (Section 22.6), and the rearrangement of the bromoamide anion in step 4 is analogous to a carbocation rearrangement (Section 7.11).
