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- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/14%3A_Developing_a_Standard_Method/14.07%3A_Chapter_Summary_and_Key_TermsThis chapter discusses the development of standard analytical methods in chemistry, focusing on optimizing experimental conditions, verifying precision and accuracy, and ensuring methods are suitable ...This chapter discusses the development of standard analytical methods in chemistry, focusing on optimizing experimental conditions, verifying precision and accuracy, and ensuring methods are suitable for general use. It outlines approaches such as one-factor-at-a-time and simplex optimization to find optimal responses.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/14%3A_Developing_a_Standard_Method/14.06%3A_Additional_ResourcesThis page provides a collection of practical experiments and discussions focused on optimizing experimental conditions in chemistry. It includes examples of various optimization techniques such as sim...This page provides a collection of practical experiments and discussions focused on optimizing experimental conditions in chemistry. It includes examples of various optimization techniques such as simplex optimization, factorial design, and fitting experimental data to response surfaces. Additionally, it discusses mathematical modeling, ANOVA calculations, and method validation in analytical chemistry.
- https://chem.libretexts.org/Courses/Los_Angeles_Trade_Technical_College/Analytical_Chemistry/2%3A_Analytical_Chemistry_2.0_(Harvey)/15%3A_Developing_a_Standard_Method/15.1%3A_Optimizing_the_Experimental_ProcedureDeveloping a standard method requires optimizing multiple aspects. Using the terminology of statisticians, we call the solution’s absorbance the system’s response. Hydrogen peroxide and sulfuric acid ...Developing a standard method requires optimizing multiple aspects. Using the terminology of statisticians, we call the solution’s absorbance the system’s response. Hydrogen peroxide and sulfuric acid are factors whose concentrations, or factor levels, determine the system’s response. To optimize the method we need to find the best combination of factor levels. Usually we seek a maximum response, but sometimes, such as minimizing an analysis’s percent error, we are looking for a minimum response.
- https://chem.libretexts.org/Courses/University_of_San_Diego/Fall_2024_Chem_220_Analytical_Chemistry_David_De_Haan/03%3A_Basic_Analytical_Tools/3.07%3A_Simplex_OptimizationTo place the initial two-factor simplex on the response surface, we choose a starting point (a, b) for the first vertex and place the remaining two vertices at (a + s a , b) and (a + 0.5s a , b + 0.87...To place the initial two-factor simplex on the response surface, we choose a starting point (a, b) for the first vertex and place the remaining two vertices at (a + s a , b) and (a + 0.5s a , b + 0.87s b ) where s a and s b are step sizes for factor A and for factor B [see, for example, Long, D. If the new vertex has the worst response, then return to the previous vertex and reject the vertex with the second worst response, (v s ) calculating the new vertex’s factor levels using rule 2.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Chemometrics_Using_R_(Harvey)/09%3A_Gathering_Data/9.04%3A_Simplex_OptimizationTo place the initial two-factor simplex on the response surface, we choose a starting point (a, b) for the first vertex and place the remaining two vertices at (a + s a , b) and (a + 0.5s a , b + 0.87...To place the initial two-factor simplex on the response surface, we choose a starting point (a, b) for the first vertex and place the remaining two vertices at (a + s a , b) and (a + 0.5s a , b + 0.87s b ) where s a and s b are step sizes for factor A and for factor B [see, for example, Long, D. If the new vertex has the worst response, then return to the previous vertex and reject the vertex with the second worst response, (v s ) calculating the new vertex’s factor levels using rule 2.
- https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Analytical_Chemistry_2.1_(Harvey)/14%3A_Developing_a_Standard_Method/14.01%3A_Optimizing_the_Experimental_ProcedureThis page discusses the quantitative analysis of vanadium by measuring the absorbance of a reddish-brown compound formed in the presence of H2O2 and H2SO4. It elaborates on optimization strategies for...This page discusses the quantitative analysis of vanadium by measuring the absorbance of a reddish-brown compound formed in the presence of H2O2 and H2SO4. It elaborates on optimization strategies for maximizing the system's response, which involves the concentrations of these reagents.
