Search
- https://chem.libretexts.org/Courses/Martin_Luther_College/Organic_Chemistry_-_MLC/03%3A_Alcohols_Ethers_Thiols_Sulfides_and_Amines/3.03%3A_Amines_and_Heterocycles/3.3.03%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/24%3A_Amines_and_Heterocycles/24.06%3A_Synthesis_of_AminesThis section covers various methods for synthesizing amines, including reductive amination of carbonyl compounds, nucleophilic substitution reactions, and the reduction of nitro compounds. It emphasiz...This section covers various methods for synthesizing amines, including reductive amination of carbonyl compounds, nucleophilic substitution reactions, and the reduction of nitro compounds. It emphasizes the significance of amines in organic synthesis and their applications in pharmaceuticals and agrochemicals. Understanding these synthetic pathways is essential for developing new amine compounds for various uses.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Basic_Principles_of_Organic_Chemistry_(Roberts_and_Caserio)/23%3A_Organonitrogen_Compounds_I_-_Amines/23.12%3A_Synthesis_of_AminesThere three main groups of synthesis routes for amines. The first group starts with a simple amine, or with ammonia, and builds up the carbon framework by alkylation or arylation reactions on nitrogen...There three main groups of synthesis routes for amines. The first group starts with a simple amine, or with ammonia, and builds up the carbon framework by alkylation or arylation reactions on nitrogen. The second group starts with compounds of the same carbon-nitrogen framework as in the desired amine, but with nitrogen in a higher oxidation state. The third group of reactions relies on the fact that amides usually can be converted to amines, either by reduction, hydrolysis, or rearrangement.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/10%3A_Amines_and_Heterocycles/10.07%3A_Synthesis_of_AminesThe Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid ...The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 ) There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/24%3A_Amines_and_Heterocycles/24.07%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_III_(Morsch_et_al.)/24%3A_Amines_and_Heterocycles/24.06%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/24%3A_Amines_and_Heterocycles/24.07%3A_Synthesis_of_AminesAn imine intermediate is first formed by a nucleophilic addition reaction (Section 19.8), and the C═N C═N bond of the imine is then reduced to the amine, much as the C═O C═O bond of a ketone can be re...An imine intermediate is first formed by a nucleophilic addition reaction (Section 19.8), and the C═N C═N bond of the imine is then reduced to the amine, much as the C═O C═O bond of a ketone can be reduced to an alcohol. Thus, the bromination of an amide in steps 1 and 2 is analogous to the base-promoted bromination of a ketone enolate ion (Section 22.6), and the rearrangement of the bromoamide anion in step 4 is analogous to a carbocation rearrangement (Section 7.11).
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/24%3A_Amines_and_Heterocycles/24.06%3A_Synthesis_of_AminesThere is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The ...There is a rearrangement step in the overall degradation process, however: this is the step in which the alkyl group of the acyl nitrene migrates from carbon to nitrogen to produce an isocyanate. The Curtius rearrangement involves an acyl azide reacting with water and heat to produce a 1 o amine along with CO 2 and N 2 . The acyl azide is usually made by a nucleophilic substitution of an acid chloride with sodium azide (NaN 3 )
