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- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/23%3A_Carbonyl_Condensation_Reactions/23.11%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/23%3A_Carbonyl_Condensation_Reactions/23.11%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/23%3A_Carbonyl_Condensation_Reactions/23.10%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/09%3A_Carbonyl_Condensation_Reactions/9.11%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/23%3A_Carbonyl_Condensation_Reactions/23.10%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionThe Michael reaction involves a conjugate addition of nucleophiles to α,β-unsaturated carbonyl compounds, leading to the formation of a new carbon-carbon bond. This reaction is valuable in organic syn...The Michael reaction involves a conjugate addition of nucleophiles to α,β-unsaturated carbonyl compounds, leading to the formation of a new carbon-carbon bond. This reaction is valuable in organic synthesis for constructing complex molecules and is typically catalyzed by bases or acids. The nucleophile adds to the β-carbon of the unsaturated system, resulting in a stable product. The reaction showcases the importance of conjugate addition in forming various functional groups.
- https://chem.libretexts.org/Ancillary_Materials/Reference/Organic_Chemistry_Glossary/Michael_Addition1,4-Addition reactions of α, β–unsaturated carbonyl compounds and α, β–unsaturated nitriles with resonance-stabilized carbon nucleophiles, such as enolate ions and enamines, are known as Michael addit...1,4-Addition reactions of α, β–unsaturated carbonyl compounds and α, β–unsaturated nitriles with resonance-stabilized carbon nucleophiles, such as enolate ions and enamines, are known as Michael addition. The α, β–unsaturated compounds undergoing Michael addition is called the Michael acceptor, the nucleophile Michael donor, and the product Michael adduct. mechanism: see also Robinson annulation
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/23%3A_Carbonyl_Condensation_Reactions/23.10%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
- https://chem.libretexts.org/Courses/University_of_Connecticut/Chem_2444%3A_(Second_Semester_Organic_Chemistry)_UConn/10%3A_Reactions_at_the_Alpha-Carbon_(Alpha_Substitutions)/10.12%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionAn acidic hydrogen is removed from the nucleophile and then it is used to form a C-C bond with the carbon in the beta position from the carbonyl. Notice that the Michael Reaction does not require the ...An acidic hydrogen is removed from the nucleophile and then it is used to form a C-C bond with the carbon in the beta position from the carbonyl. Notice that the Michael Reaction does not require the deprotonation of the product to push the reaction towards completion. The reaction is thermodynamically favorable because the C-C bond formed in the product is stronger than the C=C bond in the starting material.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Basic_Principles_of_Organic_Chemistry_(Roberts_and_Caserio)/17%3A_Carbonyl_Compounds_II-_Enols_and_Enolate_Anions._Unsaturated_and_Polycarbonyl_Compounds/17.06%3A_-Unsaturated_Aldehydes_and_KetonesThe most generally useful preparation of α,β-unsaturated carbonyl compounds is by dehydration of aldol addition products. There are many addition reactions of α, β -unsaturated aldehydes, ketones, an...The most generally useful preparation of α,β-unsaturated carbonyl compounds is by dehydration of aldol addition products. There are many addition reactions of α, β -unsaturated aldehydes, ketones, and related compounds that are the same as the carbonyl addition reactions described previously. Others are quite different and result in addition to the alkene double bond.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/01%3A_Reactions_using_Chiral_Lewis_Acids_and_Brnsted_Acid/1.01%3A_Brnsted_Acid-Assisted_Lewis_Acid_(BLA)Chiral Brønsted acid-assisted Lewis acids (BLAs) are efficient and versatile chiral Lewis acids for a wide range of catalytic asymmetric cycloaddition reactions.
- https://chem.libretexts.org/Courses/Smith_College/CHM_223_Chemistry_III%3A_Organic_Chemistry_(2024)/07%3A_Carbonyl_Condensation_Reactions/7.11%3A_Conjugate_Carbonyl_Additions_-_The_Michael_ReactionCertain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition,...Certain nucleophiles undergo conjugate addition with the alkene of an α, β-unsaturated carbonyl compounds rather than undergo direct nucleophilic addition with the carbonyl. During conjugate addition, a nucleophile adds to the electrophilic β-alkene carbon to from a C-Nuc bond. If the starting materials contains an ester the corresponding alkoxide is used as the base in the reaction. Otherwise a hydroxide base, such as sodium or potassium hydroxide, is commonly used.
