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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/24%3A_Amines_and_Heterocycles/24.07%3A_Reactions_of_AminesThis section discusses the reactions of amines, including their role as nucleophiles in various chemical reactions. It highlights amines' ability to undergo acylation, alkylation, and oxidation. Addit...This section discusses the reactions of amines, including their role as nucleophiles in various chemical reactions. It highlights amines' ability to undergo acylation, alkylation, and oxidation. Additionally, it explores the formation of salts when amines react with acids. The significance of these reactions in organic synthesis and pharmaceuticals is emphasized, showcasing amines' versatility and importance.
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/24%3A_Amines_and_Heterocycles/24.08%3A_Reactions_of_AminesUnlike what happens in other E2 reactions, the major product of Hofmann elimination is the less highly substituted alkene rather than the more highly substituted one, as shown by the reaction of (1-me...Unlike what happens in other E2 reactions, the major product of Hofmann elimination is the less highly substituted alkene rather than the more highly substituted one, as shown by the reaction of (1-methylbutyl)trimethylammonium hydroxide to give 1-pentene rather than the alternative 2-pentene. Because of the large size of the trialkylamine leaving group, the base must abstract a hydrogen from the more accessible, least hindered position.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/24%3A_Amines_and_Heterocycles/24.08%3A_Reactions_of_AminesIn a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent;...In a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent; and in the carbanion‑like transition state, the C-H bond is broken to a greater extent than the C-X bond.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_III_(Morsch_et_al.)/24%3A_Amines_and_Heterocycles/24.07%3A_Reactions_of_AminesIn a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent;...In a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent; and in the carbanion‑like transition state, the C-H bond is broken to a greater extent than the C-X bond.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/10%3A_Amines_and_Heterocycles/10.08%3A_Reactions_of_AminesIn a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent;...In a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent; and in the carbanion‑like transition state, the C-H bond is broken to a greater extent than the C-X bond.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_(Organic_Chemistry)/Reactions/Named_Reactions/Hofmann_EliminationThe chief product from the elimination is the alkene having the more highly substituted double bond, reflecting not only the 3:1 numerical advantage of those beta-hydrogens, but also the greater stabi...The chief product from the elimination is the alkene having the more highly substituted double bond, reflecting not only the 3:1 numerical advantage of those beta-hydrogens, but also the greater stability of the double bond. When the leaving group X carries a positive charge, as do the 4º-ammonium compounds discussed here, the inductive influence of this charge will increase the acidity of both the alpha and the beta-hydrogens.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/24%3A_Amines_and_Heterocycles/24.07%3A_Reactions_of_AminesIn a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent;...In a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent; and in the carbanion‑like transition state, the C-H bond is broken to a greater extent than the C-X bond.
- https://chem.libretexts.org/Courses/Martin_Luther_College/Organic_Chemistry_-_MLC/03%3A_Alcohols_Ethers_Thiols_Sulfides_and_Amines/3.03%3A_Amines_and_Heterocycles/3.3.04%3A_Reactions_of_AminesIn a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent;...In a carbocation‑like transition state, the C-X bond is broken to a greater extent than the C-H bond; in the central transition state both, the C-X bond and the C-H bond are broken to an equal extent; and in the carbanion‑like transition state, the C-H bond is broken to a greater extent than the C-X bond.
