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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Catalytic_Asymmetric_Synthesis_(Punniyamurthy)/02%3A_Asymmetric_Carbon-Carbon_Bond_Forming_Reactions/2.04%3A__Metal-Catalyzed_Asymmetric_Conjugate_Addition_ReactionsThis lecture covers some examples for the recent developments in the conjugate addition of Grignard, organozinc, organolithium, organocopper and organoborane reagents with activated alkenes in the pre...This lecture covers some examples for the recent developments in the conjugate addition of Grignard, organozinc, organolithium, organocopper and organoborane reagents with activated alkenes in the presence of chiral ligand or chiral catalysts. For example, the copper-catalyzed conjugate addition of dialkylzinc reagents to acyclic aliphatic α,β -unsaturated ketones proceed in the presence of L-9 with up to 94% ee, while the reaction using L-10 gives up to 98% ee (Scheme \PageIndex8).
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_I_(Morsch_et_al.)/10%3A_Organohalides/10.06%3A_Reactions_of_Alkyl_Halides_-_Grignard_ReagentsThe organomagnesium compounds formed by the reaction of an alkyl or aryl halide with magnesium are called Grignard reagents. As you will see throughout the remainder of this course, Grignard reagents ...The organomagnesium compounds formed by the reaction of an alkyl or aryl halide with magnesium are called Grignard reagents. As you will see throughout the remainder of this course, Grignard reagents can be used to synthesize a wide range of organic compounds and are extremely useful to the organic chemist.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/10%3A_Organohalides/10.06%3A_Reactions_of_Alkyl_Halides_-_Grignard_ReagentsThe organomagnesium compounds formed by the reaction of an alkyl or aryl halide with magnesium are called Grignard reagents. As you will see throughout the remainder of this course, Grignard reagents ...The organomagnesium compounds formed by the reaction of an alkyl or aryl halide with magnesium are called Grignard reagents. As you will see throughout the remainder of this course, Grignard reagents can be used to synthesize a wide range of organic compounds and are extremely useful to the organic chemist.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/17%3A_Alcohols_and_Phenols/17.05%3A_Alcohols_from_Carbonyl_Compounds_-_Grignard_ReagentsWith esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol fro...With esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol from a Grignard reagent involves the reaction of the Grignard reagent with ethylene oxide to produce a primary alcohol containing two more carbon atoms than the original Grignard reagent.
- https://chem.libretexts.org/Courses/SUNY_Oneonta/Chem_322_Lecture_Content/05%3A_Organohalogen_and_Organometallic_Compounds/5.12%3A_Organomagnesium_CompoundsFor many years the most important organometallic compounds for synthetic purposes have been the organomagnesium halides, or Grignard reagents. They are named after Victor Grignard, who discovered them...For many years the most important organometallic compounds for synthetic purposes have been the organomagnesium halides, or Grignard reagents. They are named after Victor Grignard, who discovered them and developed their use as synthetic reagents, for which he received a Nobel Prize in 1912. As already mentioned, these substances customarily are prepared in dry ether solution from magnesium turnings and an organic halide.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Basic_Principles_of_Organic_Chemistry_(Roberts_and_Caserio)/14%3A_Organohalogen_and_Organometallic_Compounds/14.12%3A_Organomagnesium_CompoundsFor many years the most important organometallic compounds for synthetic purposes have been the organomagnesium halides, or Grignard reagents. They are named after Victor Grignard, who discovered them...For many years the most important organometallic compounds for synthetic purposes have been the organomagnesium halides, or Grignard reagents. They are named after Victor Grignard, who discovered them and developed their use as synthetic reagents, for which he received a Nobel Prize in 1912. As already mentioned, these substances customarily are prepared in dry ether solution from magnesium turnings and an organic halide.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/17%3A_Alcohols_and_Phenols/17.06%3A_Alcohols_from_Carbonyl_Compounds-_Grignard_ReagentsWith esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol fro...With esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol from a Grignard reagent involves the reaction of the Grignard reagent with ethylene oxide to produce a primary alcohol containing two more carbon atoms than the original Grignard reagent.
- https://chem.libretexts.org/Courses/Smith_College/CHM_222_Chemistry_II%3A_Organic_Chemistry_(2025)/09%3A_Alcohols_and_Phenols/9.06%3A_Alcohols_from_Carbonyl_Compounds_-_Grignard_ReagentsWith esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol fro...With esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol from a Grignard reagent involves the reaction of the Grignard reagent with ethylene oxide to produce a primary alcohol containing two more carbon atoms than the original Grignard reagent.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/17%3A_Alcohols_and_Phenols/17.05%3A_Alcohols_from_Carbonyl_Compounds_-_Grignard_ReagentsWith esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol fro...With esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol from a Grignard reagent involves the reaction of the Grignard reagent with ethylene oxide to produce a primary alcohol containing two more carbon atoms than the original Grignard reagent.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/19%3A_Aldehydes_and_Ketones-_Nucleophilic_Addition_Reactions/19.07%3A_Nucleophilic_Addition_of_Hydride_and_Grignard_Reagents_-_Alcohol_Formationwrite the general mechanism of nucleophilic addition of the “hydride ion” in the reduction of a carbonyl group. The breaking of the C=O double bond allows for the formation of two new single bonds in ...write the general mechanism of nucleophilic addition of the “hydride ion” in the reduction of a carbonyl group. The breaking of the C=O double bond allows for the formation of two new single bonds in the product. Attack by the hydride can occur from either the re or the si face of an asymmetrical carbonyl, leading to a mixture of the (S) and (R) alcohols. The carbanion nucleophile from the Grignard reagent adds to the electrophilic carbon of the acid-base complex forming a C-C bond.
- https://chem.libretexts.org/Workbench/Chemistry_LHS_Bridge/15%3A_Alcohols_and_Phenols/15.06%3A_Alcohols_from_Carbonyl_Compounds_-_Grignard_ReagentsWith esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol fro...With esters, after the first Grignard reaction, the carbonyl reforms creating a ketone which can then react with a second molecule of the Grignard. Another important route for producing an alcohol from a Grignard reagent involves the reaction of the Grignard reagent with ethylene oxide to produce a primary alcohol containing two more carbon atoms than the original Grignard reagent.
