The synthesis of trifluoromethyl-substituted 2-isoxazolines can be accomplished by a domino Michael–cyclization–dehydration reaction of hydroxylamine (NH 2 OH) with a range of (E)- trifluoromethylated...The synthesis of trifluoromethyl-substituted 2-isoxazolines can be accomplished by a domino Michael–cyclization–dehydration reaction of hydroxylamine (NH 2 OH) with a range of (E)- trifluoromethylated enone derivatives in the presence of N -3,5-bis(trifluoromethyl benzyl) quinidinium bromide L6 as a chiral phase transfer catalyst (Scheme \PageIndex9).
