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21.16: Cyclic Hemiacetals

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  • Formation of Cyclic Hemiacetal and Acetals

    Molecules which have an alcohol and a carbonyl can undergo an intramolecular reaction to form a cyclic hemiacetal.


    Intramolecular Hemiacetal formation is common in sugar chemistry. For example, the common sugar glucose exists in the cylcic manner more than 99% of the time in a mixture of aqueous solution.


    Carbonyls reacting with diol produce a cyclic acetal. A common diol used to form cyclic acetals is ethylene glycol.


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