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Chemistry LibreTexts

8.01 Functional Group Transformation by Nucleophilic Substitution

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  • Nucleophiles are often anion, but not necessarily.

    Some examples:

    Alkoxide ions

    carboxylate ions

    cyanide ion

    azide ion

    Nucleophilic Substitution - leaving group must be on an sp3-hypridized carbon. If the Leaving group is on an sp2-hybridized carbon Nucleophilic substitution will not occur.

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